Results 1 to 10 of about 16,507 (195)

Safety evaluation of the food enzyme microbial collagenase from the genetically modified Streptomyces violaceoruber strain pCol [PDF]

EFSA Journal
The food enzyme microbial collagenase (EC 3.4.24.3) is produced with the genetically modified Streptomyces violaceoruber strain pCol by Nagase (Europa) GmbH. The genetic modifications do not give rise to safety concerns.
EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), Claude Lambré, José Manuel Barat Baviera, Claudia Bolognesi, Pier Sandro Cocconcelli, Riccardo Crebelli, David Michael Gott, Konrad Grob, Evgenia Lampi, Marcel Mengelers, Alicja Mortensen, Gilles Rivière, Inger‐Lise Steffensen, Christina Tlustos, Henk Van Loveren, Laurence Vernis, Holger Zorn, Lieve Herman, Yrjö Roos, Jaime Aguilera, Magdalena Andryszkiewicz, Daniele Cavanna, Cristina Fernàndez‐Fraguas, Silvia Peluso, Elsa Nielsen, Karin Nørby, Giulio diPiazza, Laura Sanmartín Cabo, Yi Liu, Andrew Chesson   +29 more
doaj   +8 more sources

Discovery of New Microbial Collagenase Inhibitors [PDF]

Life, 2022
Bacterial virulence factors are mediating bacterial pathogenesis and infectivity. Collagenases are virulence factors secreted by several bacterial stains, such as Clostridium, Bacillus, Vibrio and Pseudomonas.
Georgiana Nitulescu, Dragos Paul Mihai, Anca Zanfirescu, Miruna Silvia Stan, Daniela Gradinaru, George Mihai Nitulescu   +5 more
doaj   +4 more sources

Candidates for Repurposing as Anti-Virulence Agents Based on the Structural Profile Analysis of Microbial Collagenase Inhibitors [PDF]

Pharmaceutics, 2021
The pharmacological inhibition of the bacterial collagenases (BC) enzymes is considered a promising strategy to block the virulence of the bacteria without targeting the selection mechanism leading to drug resistance.
Georgiana Nitulescu, George Mihai Nitulescu, Anca Zanfirescu, Dragos Paul Mihai, Daniela Gradinaru   +4 more
doaj   +5 more sources

Microbial collagenase activity is linked to oral-gut translocation in advanced chronic liver disease. [PDF]

Nat Microbiol
Abstract Microbiome perturbations are associated with advanced chronic liver disease (ACLD), but how microorganisms contribute to disease mechanisms is unclear. Here we analysed metagenomes of paired saliva and faecal samples from an ACLD cohort of 86 individuals, plus 2 control groups of 52 healthy individuals ...
Jin S, Cenier A, Wetzel D, Arefaine B, Moreno-Gonzalez M, Stamouli M, Mohamad M, Lupatsii M, Ríos E, Lee S, Zamalloa A, Chokshi S, Mardinoglu A, Shoaie S, Beraza N, Patel VC, Schirmer M.   +16 more
europepmc   +3 more sources

Microbial Exploitation of Feather Wastes for Sustainable Production of Keratinase and Collagenase Enzymes by Didymella keratinophila AUMC 15399 in Submerged Fermentation

Fermentation, 2023
A distinctive isolate was discovered and visually recognized as a member of the genus Didymella during a routine examination of Coelomycetes isolated from diverse fruit juices.
Osama Abdel-Hafeez Mohamed Al-Bedak, Ahmed Mohamed Moharram, Nemmat Abdel-Gawad Hussein, Doaa Mohamed Taha, Steven L. Stephenson, Fuad Ameen   +5 more
doaj   +2 more sources

The action of microbial collagenases in dentinal matrix degradation in root caries and potential strategies for its management: a comprehensive state-of-the-art review [PDF]

Journal of Applied Oral Science
Conventional views associate microbial biofilm with demineralization in root caries (RC) onset, while research on their collagenases role in the breakdown of collagen matrix has been sporadically developed, primarily in vitro. Recent discoveries, however,
Cecília de Brito BARBOSA, Isabela MONICI SILVA, Naile DAME-TEIXEIRA   +2 more
doaj   +3 more sources

CLINICAL RESULTS OF COLLAGENASE TREATMENT FOR DUPUYTREN’S DISEASE: A CASE SERIES STUDY WITH 2-YEARS FOLLOW-UP [PDF]

Acta Ortopédica Brasileira, 2023
Objectives: This study aims to report our experience with Clostridium Histolyticum collagenase (CCH) to support the importance of its clinical use and assess its clinical efficacy, complications, and recurrences.
Morena Anna Basso, Alessio Bernasconi, Giovanni Balato, Andrea Cozzolino, Giulia Famiglietti, Francesco Smeraglia   +5 more
doaj   +1 more source

Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo studies

Frontiers in Cellular and Infection Microbiology, 2023
Introduction and aimThe presence of host collagenases in the degradation of the protein matrix at later stages of carious dentin lesions development, as well as the potential involvement of bacterial collagenases, have been suggested but lack conclusive ...
Cecília de Brito Barbosa, Isabela Monici Silva, Jéssica Alves de Cena, Cristine Miron Stefani, Naile Dame-Teixeira   +4 more
doaj   +1 more source

Antioxidant and Antimicrobial Activities of Enzymatic Hydrolysates of Camelʼs Milk Whey Protein and Casein [PDF]

Journal of Food and Dairy Sciences, 2020
Healthy skimmed camel milk’s, casein and whey proteins precipitated and freeze dried, and were treated with 1% of five proteolytic microbial renin, pepsin, trypsin, collagenase and microbial protease.
A. Abd EL Rahim
doaj   +1 more source

Differences in the degradation of native collagen by two microbial collagenases [PDF]

Biochemical Journal, 1979
The early stages of degradation of native collagen by two bacterial collagenases were studied by electron microscopy and by automatic Edman degradation. The purified collagenase from Clostridium histolyticum was shown to cleave native collagen at several sites, but not progressively from the N-terminus, as had been previously suggested. The homogeneous
A, Lecroisey, B, Keil
openaire   +2 more sources