Results 191 to 200 of about 11,362 (251)

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Enhancing the outcomes of diabetic vitrectomy with pharmacological adjuvants. [PDF]

World J Methodol
Cheng CY, Hao WR, Cheng TH.
europepmc   +1 more source

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

METTL7A Downregulation Drives SLC1A5‐Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8+ T Cell Immunity in Gastric Cancer

Advanced Science, EarlyView.
GC cells enhance glutamine accumulation by upregulating SLC1A5 expression. This upregulation not only boosts GC cell proliferation, but also outcompetes CD8+ T cells for glutamine and suppresses their antitumor immunity. Mechanistically, METTL7A deficiency in GC induces SLC1A5 overexpression via an m6A‐dependent pathway and N‐glycosylation ...
Mingjun Sun, Shuwei Dang, Dazhi Zhou, Lixian Ding, Xun Sun, Wei Suo, Jirui Niu, Qingzhu Yang, Zhicheng Zhang, Yanyan Sun, Jinxing Li, Zhongsheng Chen, Tao Ban, Yingji Wang, Tianzhu Li, Ming Liu, Guodong Li   +16 more
wiley   +1 more source

From the Ground to the Clinic: The Evolution and Adaptation of Fungi. [PDF]

J Fungi (Basel)
Corrêa-Junior D, Zamith-Miranda D, Frases S, Nosanchuk JD.   +3 more
europepmc   +1 more source

Tigecycline Induced Hemorrhagic Vesiculobullous Leukocytoclastic Vasculitis: A Rare Clinical Presentation. [PDF]

Oman Med J
Al Maqbali H, Al Majrabi B, Al Waili A, Qureshi A, Balkhair A, Al Busaidi I.   +5 more
europepmc   +1 more source

Comparative Effects of Riboflavin-UVA and Rose Bengal-Green Light Cross-Linking on Corneal Neovascularization. [PDF]

Invest Ophthalmol Vis Sci
Oral M, Dayanir D, Arik Erol GN, Özmen MC.   +3 more
europepmc   +1 more source

Collagen in pituitary adenomas: A comprehensive review of biological roles and clinical implications. [PDF]

J Clin Transl Endocrinol
Liu J, Yao Y, Duan L, Lu L, Zhu H, Li Y, Gao J.   +6 more
europepmc   +1 more source

Effects of mussel-inspired compounds on dentin bonding: a systematic review and meta-analysis. [PDF]

BMC Oral Health
Peng F, Long Y, Gao H, Huang S, Wei Y, Lu C, He J, Ma Y, Lin Y, Liang L, Chen Z, Li K.   +11 more
europepmc   +1 more source

Towards host-directed therapy: The role of matrix metalloproteinases in the immunopathogenesis of tuberculosis.

Int J Infect Dis
Loader MI, Chong DLW, Skolimowska KH, Friedland JS.   +3 more
europepmc   +1 more source