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Biochimie, 2005
Three mammalian collagenases (MMP-1, MMP-8, and MMP-13) belong to family of matrix metalloproteinases and are the principal secreted endopeptidases capable of cleaving collagenous extracellular matrix. In addition to fibrillar collagens, collagenases can cleave several other matrix and non-matrix proteins including growth factors, and this way regulate
Veli-Matti Kahari, Risto Ala-Aho
exaly +3 more sources
Three mammalian collagenases (MMP-1, MMP-8, and MMP-13) belong to family of matrix metalloproteinases and are the principal secreted endopeptidases capable of cleaving collagenous extracellular matrix. In addition to fibrillar collagens, collagenases can cleave several other matrix and non-matrix proteins including growth factors, and this way regulate
Veli-Matti Kahari, Risto Ala-Aho
exaly +3 more sources
Experimental Eye Research, 1969
A collagenase that can digest both collagen fibers in the stroma and the native collagen molecule was found in rabbit corneal epithelium, using a tissue culture assay. Calf, chicken and fetal calf serum added to the tissue culture media inhibited the collagenase, while human and rabbit serum were not inhibitory.
M, Itoi +4 more
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A collagenase that can digest both collagen fibers in the stroma and the native collagen molecule was found in rabbit corneal epithelium, using a tissue culture assay. Calf, chicken and fetal calf serum added to the tissue culture media inhibited the collagenase, while human and rabbit serum were not inhibitory.
M, Itoi +4 more
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Chick bone collagenase inhibitor and latency of collagenase
Biochemical and Biophysical Research Communications, 1981Abstract Collagenase and collagenase inhibitor were isolated from the culture fluid of embryonic chick bone. The inhibitor, separated as a high molecular weight aggregate (160,000–200,000 daltons) during gel filtration in 1M NaCl, dissociated in 6M urea to species of approx 25,000 daltons.
S, Sakamoto +4 more
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Collagenase and Collagenase Inhibitors in Bronchoalveolar Lavage Fluids
Chest, 1991Collagenase, collagenolytic activity and tissue inhibitor of metalloproteinases were evaluated in bronchoalveolar lavage from 25 patients with hypersensitivity pneumonitis and four control subjects. Patients were followed between two and three years, after which they were classified as "healed," "improved," or "worsened." In control samples ...
M, Selman +7 more
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Bacterial collagenases – A review
Critical Reviews in Microbiology, 2014Bacterial collagenases are metalloproteinases involved in the degradation of the extracellular matrices of animal cells, due to their ability to digest native collagen. These enzymes are important virulence factors in a variety of pathogenic bacteria. Nonetheless, there is a lack of scientific consensus for a proper and well-defined classification of ...
Duarte, Ana Sofia +2 more
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Chemonucleolysis (Discolysis) with Collagenase
Spine, 1986Fifty-four patients with proven lumbar disc displacement were treated by intradiscal injection of collagenase (Nucleolysin) between April 1981 and January 1984. Follow-up by history and physical examination, phone survey, and/or mail survey shows 72% success rate (excellent, good, and fair) and 28% poor or unsuccessful results.
M D, Brown, J S, Tompkins
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The preparation of purified collagenase
Archives of Biochemistry and Biophysics, 1963Abstract Two methods are described for the purification of Clostridium histolyticum collagenase. One method involves gel filtration on columns of Sephadex G-200, the other, ion-exchange chromatography on DEAE Sephadex A-50. In both cases, calcium-containing buffers were found necessary for good recoveries of enzyme.
S, KELLER, I, MANDL
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