Results 61 to 70 of about 1,679,257 (316)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Kahramanmaraş—Gaziantep, Türkiye M_w 7.8 Earthquake on 6 February 2023: Strong Ground Motion and Building Response Estimations

Buildings, 2023
The effects on structures of the earthquake with the magnitude of 7.8 on the Richter scale (moment magnitude scale) that took place in Pazarcık, Kahramanmaraş, Türkiye at 04:17 a.m.
George Papazafeiropoulos, Vagelis Plevris   +1 more
doaj   +1 more source

Exact analytical solution of the collapse of self-gravitating Brownian particles and bacterial populations at zero temperature

, 2011
We provide an exact analytical solution of the collapse dynamics of self-gravitating Brownian particles and bacterial populations at zero temperature.
C. Sire, Clément Sire, D. Lynden Bell, D. Lynden Bell, D. Lynden Bell, E. Bettwieser, H. Risken, J. Binney, J. P. Hansen, L. Mestel, L. Spitzer, M. Hénon, M. V. Penston, P. Debye, P. H. Chavanis, P. H. Chavanis, Pierre-Henri Chavanis, S. Chandrasekhar, S. Inagaki, T. D. Frank, V. A. Antonov   +20 more
core   +3 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

The Role of Foreign Harem and Queen In The Fall of The Ottoman Empire: A Siyasah Shar'iyyah Perspective

Ulumuddin
The article from this research aims to explain the role of women and foreign women in the Ottoman government, which had positive and negative impacts on the Empire. At first, the role of women was not very prominent in government.
Rahmi Rahmi, Ilhamni Ilhamni, Meirison Meirison, Roza Humairoh   +3 more
doaj   +1 more source

Nonlinear Criterion for the Stability of Molecular Clouds

, 2005
Dynamically significant magnetic fields are routinely observed in molecular clouds, with mass-to-flux ratio lambda = (2 pi sqrt{G}) (Sigma/B) ~ 1 (here Sigma is the total column density and B is the field strength).
Charles F. Gammie, Mestel L., Nakano T., Nakano T., Ruben Krasnopolsky   +4 more
core   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Sustainability through institutional failure and decline? Archetypes of productive pathways

Ecology and Society, 2019
Although current literature on sustainability governance and institutions is preoccupied with innovation, novelty, success, and "best practice," there is an emergent tendency to consider decline and failure as opportunities and leverage points to work ...
Jens Newig, Pim Derwort, Nicolas W. Jager   +2 more
doaj   +1 more source

Agreement Among Radiographs, Fluoroscopy and Bronchoscopy in Documentation of Airway Collapse in Dogs. [PDF]

, 2015
BackgroundAirway collapse is a common finding in dogs with chronic cough, yet the diagnosis can be difficult to confirm without specialty equipment.HypothesisBronchoscopic documentation of tracheobronchial collapse will show better agreement with ...
Johnson, LR, Pollard, RE, Singh, MK
core  

Spherical collapse model with shear and angular momentum in dark energy cosmologies

, 2012
We study, for the first time, how shear and angular momentum modify typical parameters of the spherical collapse model, in dark energy dominated universes.
Del Popolo, A., Lima, J. A. S., Pace, F.
core   +1 more source