Results 31 to 40 of about 1,692,148 (291)

CPX‐351 in High‐Risk Relapsed Pediatric Acute Leukemia: Real‐World Phase 1 Data Establishing the FDA‐Approved Dose

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Outcomes for pediatric relapsed/refractory (R/R) acute myeloid leukemia (AML) remain dismal. CPX‐351, a liposomal formulation of cytarabine and daunorubicin, may have less off‐target toxicities than traditional chemotherapies and has shown improved outcomes for adults with newly diagnosed therapy‐related AML.
Jonathan D. Bender, Lauren Pommert, Lori R. Backus, Andrea Bidwell, Courtney Blank, Erin H. Breese, Karen C. Burns, Adam Lane, Lynn H. Lee, Benjamin Mizukawa, Robin E. Norris, Maureen M. O'Brien, Daniel Peck, Christine Phillips, Thomas D. Ryan, Jennifer Young, Michael Absalon, John P. Perentesis   +17 more
wiley   +1 more source

Water governance and institutional change [PDF]

, 2004
This dissertation is about water governance and institutional change. The focus on water governance means that we are interested in collective action with respect to water issues, which is not restricted to government action by public authorities, but ...
Kuks, S.M.M.
core   +1 more source

Double Relative Deprivation: Combining the Personal and Political [PDF]

, 1995
Double relative deprivation, which has been virtually ignored in research on relative deprivation, was expected to predict women\u27s collective action over and above egoistic and collective deprivation.
Foster, Mindi D, Matheson, Kimberley
core   +2 more sources

Supporting the Upscaling of Citizen Science to Address Global Challenges

Citizen Science: Theory and Practice
In May 2024, a workshop was held as part of the European Citizen Science Association (ECSA) 2024 conference in Vienna to explore the creation of transnational communities to upscale citizen science, to address global issues as outlined by the European ...
James Christopher Sprinks, Liz Dowthwaite, Luigi Ceccaroni, Tim Kiessling, Dilek Fraisl, Giovanni Maccani, Ana Solange Leal, Agueda Gras-Velazquez, Arianna Liconti, Katarzyna Pydzinska Azevedo, Kaushiki Das, Stephen Parkinson, Mariana Malta   +12 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Trends in hepatitis C virus seroprevalence and associated risk factors among msm in Pakistan: insights from a community-based study

Scientific Reports
Pakistan bears a substantial burden of hepatitis C virus (HCV) infection, with the second-highest prevalence globally. This community-based cross-sectional study, conducted from January to December 2022 in Punjab, Pakistan, investigates the ...
Raza Tirmizi, Rimsha Munir, Nousheen Zaidi   +2 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Hope and Anger as Mediators Between Collective Action Frames and Participation in Collective Mobilization: The Case of 15-M

Journal of Social and Political Psychology, 2017
The study set out to integrate collective action models and emphasize the role of emotions. Whereas the importance of anger is indisputable, relatively little attention has been paid to the role of positive emotions, such as hope, in collective action ...
Anna Wlodarczyk, Nekane Basabe, Darío Páez, Larraitz Zumeta   +3 more
doaj   +1 more source

Modes of Collective Action in Village Economies: Evidence from Natural and Artefactual Field Experiments in a Developing Country [PDF]

Asian Development Review, 2013
In a canonical model of collective action, individual contribution to collective action is negatively correlated with group size. Yet, empirical evidence on the group size effect has been mixed, partly due to heterogeneities in group activities.
Yasuyuki Sawada, Ryuji Kasahara, Keitaro Aoyagi, Masahiro Shoji, Mika Ueyama   +4 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source