Results 51 to 60 of about 101,249 (267)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Dispute over Fulfilment of Collective Agreement Obligations Which Do Not Result in Arising Claims to Individual Employees [PDF]
Societas et Iurisprudentia, 2018 The scientific paper deals with the issue of a new definition of the collective dispute over the fulfilment of obligations that do not give rise to claims to individual employees.
Jan Horecký +2 more
doaj
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Negocierea colectivă în sectorul bugetar
Revista Transilvană de Ştiinţe Administrative, 2013 In the context of a changing society, legislative changes have a significant impact on social dialogue between social partners. 2011 is a landmark year for the significant chan- ges that were brought to the field of labor law in Romania, reflected in ...
Iulia BĂDOI
doaj
The EU Minimum Wage Directive – Implementation in Sweden post C-19/23
Italian Labour Law e-JournalThe contribution focuses on the transposition of the EU Minimum Wage Directive into Swedish law.
Niklas Selberg
doaj +1 more source
Socio-economic value of low-intensity railway lines
Ученые записки Российской академии предпринимательства, 2021 This article describes socio-economic issues associated with low-intensity railway lines. Key stakeholders engaged in operation and maintenance of low-intensity railway lines were analyzed. The main expectations of all stakeholders were defined.
K. V. Fionova
doaj
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Régulation du télétravail et dialogue social. Le cas de la Belgique
Revue Interventions Économiques, 2006 Within a Belgian context, telework has been primarily developed in an informal way. Most importantly, it has involved workers who have autonomy in their organization of work.
Jan De Schampheleire, Esteban Martinez
doaj +1 more source