Results 61 to 70 of about 101,249 (267)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Consultation to consensus: A Comprehensive Guide to Using Collective Decision Making Methods [PDF]

Development Strategies in Medical Education
Introduction: The emergence of complex issues has led to the expansion of consensus and collective agreement methods; however, many researchers still mistakenly use these methods interchangeably.
Seyedeh Zahra Nahardani, Seyedeh Mahboobeh Hosseini, Maryam Beheshtifar, Mehdi Gassabichorsi   +3 more
doaj  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Collective agreement role in ensuring stability of labor relations in a state medical organization

RUDN Journal of Medicine
Relevance. The relevance of the work is due to the fact that the collective agreement is akey document regulating the legal relations between employees and employers.
Timofey A. Bezuglyy, Yuri A. Tyukov
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Employer membership and collective bargaining in Italy: empirical evidence from an INAPP survey

Labour & Law Issues, 2018
Decentralization of collective bargaining is considered a key element to introduce innovations and changes work’s organization. Since 2011, European institutions too have promoted the dissemination of collective agreements more sensitive to corporate ...
Francesca Bergamante, Manuel Marocco
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

İŞYERİ DEVRİ VE KAMUDA ÇALIŞAN ALT İŞVEREN İŞÇİLERİNİN KADROYA GEÇİŞİ BAĞLAMINDA İŞVEREN DEĞİŞİKLİĞİNİN TOPLU İŞ SÖZLEŞMESİNE ETKİSİ

Türk-Alman Üniversitesi Hukuk Fakültesi Dergisi, 2019
İşçilerin örgütlenerek çalışma koşullarını iyileştirmelerinde bir araç olan toplu iş sözleşmesinin imzalanmasından önceki sürecin yanı sıra, sözleşmenin devamlılığının sağlanması da önem taşır.
Esra Yiğit
doaj