Results 51 to 60 of about 39,976 (215)

Analysis of medical exposure levels of the Russian Federation population in 2023 using the updated form No. 3–DOZ

Радиационная гигиена
Introduction: To successfully address the challenges of optimizing radiation protection during medical exposure, it is essential to have information on patient exposure levels and the structure of diagnostic radiology in medical organizations across the ...
A. V. Vodovatov, E. A. Kosarlukova, A. M. Biblin, R. R. Akhmatdinov, A. A. Bratilova   +4 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

ESTIMATION OF THE CONVERSION COEFFICIENTS FROM DOSE-AREA PRODUCT TO EFFECTIVE DOSE FOR BARIUM MEAL EXAMINATIONS FOR ADULT PATIENTS

Радиационная гигиена, 2018
Fluoroscopic examinations of the upper gastro-intestinal tract and, especially, barium meal examinations, are commonly performed in a majority of hospitals. These examinations are associated both with substantial individual patient doses and contribution
A. V. Vodovatov, V. Yu. Golikov, I. G. Kamyshanskaya, K. V. Zinkevich, Ch. Bernhardsson   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Dynamics of medical exposure of the population of the Rostov region for the period 2019-2024

Радиационная гигиена
The contribution of medical exposure to the collective effective dose is increasing both in the Russian Federation and in the Rostov Region, as confirmed by the results of the annual radiation-hygienic passportization.   The objective of this study is to
M. V. Kalinina, T. B. Namatyan, E. V. Kovalev, T. V. Zhukova, S. A. Musienko, A. B. Namatyan   +5 more
doaj   +1 more source

Análise dos registros de dose ocupacional externa no Brasil

Brazilian Journal of Radiation Sciences, 2015
Brazil, a continental country, with actually more than 150,000 workers under individual monitoring for ionizing radiation, has implemented in 1987 a centralized system for storage of external occupational dose.
Claudia Lucia de Pinho Mauricio, Herica Luiza Ramos da Silva, Claudio Ribeiro da Silva   +2 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source