Results 61 to 70 of about 8,267,972 (303)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Trends in diagnostic nuclear medicine in Sweden (2008–2023): utilisation, radiation dose, and methodological insights

EJNMMI Physics
Background Diagnostic imaging is a dynamic medical field. In nuclear medicine, advancements introduce new procedures utilising innovative radiopharmaceuticals.
Anja Almén
doaj   +1 more source

Evaluation of radiation dose to Korean population by general radiography

Nuclear Engineering and Technology
General radiography has the highest usage among diagnostic radiology in Korea, resulting in high radiation dose by general radiography. For the medical radiation safety of patients, it is necessary to evaluate Korean population dose by general ...
Hyung Woo Nam, Min Woo Kwak, Shin Dong Lee, Ju Young Kim, Kwang Pyo Kim   +4 more
doaj   +1 more source

European annual cosmic-ray dose: estimation of population exposure

Journal of Maps, 2017
The earth is continually bombarded by high-energy cosmic ray particles, and the worldwide average exposure to cosmic rays represents about 13% of the total annual effective dose received by the population.
Giorgia Cinelli, Valeria Gruber, Luca De Felice, Peter Bossew, Miguel Angel Hernandez-Ceballos, Tore Tollefsen, Stefan Mundigl, Marc De Cort   +7 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Effects of staff education and standardizing dosing and collection times on vancomycin trough appropriateness in ward patients

Pharmacy Practice, 2017
Many institutions have guidelines for initiation and monitoring, but not timing, of vancomycin.Our objective was to evaluate vancomycin trough collection appropriateness before and after an initiative to change the dosing and trough collection times in ward patients.A retrospective cohort study of ward patients from May 2014-16 who received scheduled ...
Drayton A. Hammond, Lexis N. Atkinson, Taylor B. James, Jacob T. Painter, Katherine Lusardi   +4 more
openaire   +5 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

LARCalc, a tool to estimate sex- and age-specific lifetime attributable risk in populations after nuclear power plant fallout

Scientific Reports, 2023
A tool called LARCalc, for calculating the radiological consequences of accidental large scale nuclear power plant releases based on estimates of 137Cs ground deposition, is presented.
Jonathan Sundström, Mats Isaksson, Christopher L. Rääf   +2 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Collective dose as a performance measure for occupational radiation protection programs: Issues and recommendations

, 1998
Collective dose is one of the performance measures used at many US Department of Energy (DOE) contractor facilities to quantitatively assess the objectives of the radiation protection program.
Kathren, R. L., Peffers, M. S., Martin, J. B., Hickey, E. E., Harty, R., Strom, D. J.   +5 more
core   +1 more source