Results 91 to 100 of about 2,598,009 (293)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Collective resilience in the disaster recovery period: Emergent social identity and observed social support are associated with collective efficacy, wellbeing, and the provision of social support [PDF]

, 2020
Social support and an emerging sense of community are common in flooding, but post-flood group dynamics have not been fully addressed. In the context of a flooded community, we explore how social identification with one’s community emerges and affects ...
G. James Rubin, Saavedra, Patricio, Patricio Saavedra, John Drury, Richard Williams (29445), Amlôt, Richard, Rubin, G. James; id_orcid, Williams, R., Rubin, G. James, G James Rubin (12126875), Patricio Saavedra (6117107), Evangelos Ntontis (12152776), Drury, J., Amlot, R., Saavedra, P., Rubin, J., Williams, Richard, John Drury (4460821), Drury, John, Ntontis, Evangelos, Richard Williams, Evangelos Ntontis, Richard Amlôt (530327), Richard Amlôt, Ntontis, E.   +24 more
core   +1 more source

Social Cognitive Theory: An Agentic Perspective

Ψυχολογία: το Περιοδικό της Ελληνικής Ψυχολογικής Εταιρείας, 2020
IS AVAILABLE IN THE ...
Albert Bandura
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The Relative Association of Collective Efficacy in School and Neighborhood Contexts With Adolescent Alcohol Use

Journal of Epidemiology, 2019
Background: It is unclear whether either neighborhood collective efficacy or school collective efficacy is associated with adolescent alcohol use. This study aimed to examine the relative contributions of collective efficacy, both in school and in the ...
Minoru Takakura, Masaya Miyagi, Masaru Ueji, Minoru Kobayashi, Atsushi Kurihara, Akira Kyan   +5 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

The Relationship Between Collective Efficacy and Teachers’ Social Networks in Urban Middle Schools

AERA Open, 2017
Collective efficacy, a group’s belief in its capabilities to reach a goal, is an important organizational property repeatedly linked with student achievement. However, little scholarship specifies the antecedents of collective efficacy. To fill this gap,
Dan Berebitsky, Serena J. Salloum
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Is Collective Efficacy Age Graded? The Development and Evaluation of a New Measure of Collective Efficacy for Older Adults

Journal of Aging Research, 2012
Objectives. Community processes are key determinants of older adults’ ability to age in place, but existing scales measuring these constructs may not provide accurate, unbiased measurements among older adults because they were designed with the concerns of child-rearing respondents in mind.
Adena M. Galinsky, Kathleen A. Cagney, Christopher R. Browning   +2 more
openaire   +3 more sources

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source