Results 81 to 90 of about 2,598,009 (293)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Collective urban green revitalisation: Crime control an sustainable behaviours in lower-income neighbourhoods [PDF]
The growing need to increase green spaces in highly urbanised cities has become more prominent recently. Special attention is paid to involving communities in the design process to enhance societal changes for a meaningful appreciation of the natural ...
Chilton, John +2 more
core +1 more source
Perceived efficacy and attitudes towards genetic science and science governance [PDF]
, 2010 This is the postprint version of the Article. The official published version can be obtained from the link below - © 2010 SAGE Publications.Arguments for public involvement in science and technology are often based on ideas of developing a more capable ...
Barnett, Julie +4 more
core +1 more source
Journal of Open, Flexible and Distance Learning, 2016 As digital technologies develop and change, so do the ways these tools are integrated into classrooms. In particular, as mobile digital technologies become ubiquitous there is a need to investigate how teachers engage with these tools—both personally ...
Jo Tilton, Maggie Hartnett
doaj
A study on the relationship between teachers’ job attitude, sense of efficacy and collective efficacy with their job commitment [PDF]
فصلنامه نوآوریهای آموزشی, 2012 The aim of the present research, was identifying the relationship between teachers’ job attitude, sense of efficacy, collective efficacy, and their job commitment. The research sample consisted of 220 guidance school teachers (120 female, 100 male) who
Elaheh Hejazi +2 more
doaj
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Being Positively Moved by Climate Protest Predicts Peaceful Collective Action
Global Environmental PsychologyPeople can be motivated to engage in collective action for climate protection because they are angry about an injustice or because they are emotionally moved by the idea that they can achieve something together. However, previous research on emotions and
Helen Landmann, Jascha Naumann
doaj +1 more source
Broken Windows and Collective Efficacy
SAGE Open, 2015 The broken windows thesis posits that signs of disorder increase crime and fear, both directly and indirectly. Although considerable theoretical evidence exists to support the idea that disorder is positively related to fear of crime, the empirical ...
Aldrin Abdullah +3 more
doaj +1 more source
Collective efficacy and arson: the case of Malmö [PDF]
Journal of Scandinavian Studies in Criminology and Crime Prevention, 2017 AbstractThe burning of cars and containers during social unrest has become a topic of both scholarly and public interest in Sweden over the past decade. Studies have suggested that social disorganization theory, or its modern expression collective efficacy, may be important for explaining why some neighbourhoods experience elevated levels of arson and ...
openaire +3 more sources