Results 101 to 110 of about 489,884 (348)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Motivational Aspects of Teacher Collaboration [PDF]

, 2019
The mutual dependency of teacher collaboration and motivation has emerged as a promising research field. This article now sets out to systematically review peer-reviewed articles on the interconnection of these concepts.
Kolleck, Nina
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Impact of Social Structure Characteristics of High School and University Students Playing Fencing Sports on Collective Efficacy and Goal Orientation

Türk Spor ve Egzersiz Dergisi, 2022
The aim of this study is to determine whether the social structural characteristics of high school and university students who participate in fencing are related to their collective efficacy and goal orientation.
Dilara Ilıkkan, Mehtap Yıldız
doaj  

Families and Social Media Use: The Role of Parents' Perceptions about Social Media Impact on Family Systems in the Relationship between Family Collective Efficacy and Open Communication [PDF]

, 2019
Communication through social media characterizes modern lifestyles and relationships, including family interactions. The present study aims at deepening the role that parents’ perceptions about social media effects on family systems can exert within their
Di Napoli, Immacolata, Gatti, Flora, Procentese, Fortuna   +2 more
core   +2 more sources

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Beyond Collective Efficacy: New Brief Measures to Assess the Outer Layers of the Social Ecology [PDF]

, 2015
Introduction: Community support can be a valuable interpersonal resource anywhere, yet past research has largely been focused on adults in urban neighborhoods.
Banyard, Victoria L., Grych, John, Hamby, Sherry L, Roberts, Lindsey T   +3 more
core   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Collective Efficacy of TEFL Students in Collaborative Content Learning Classroom [PDF]

Research in English Language Pedagogy
Collaborative content learning (CCL) has recently gained prominence in the research literature as a process of learning that contributes to effective learning of the content of the courses in EFL contexts.
Rogayeh Eslami, Mahnaz Saeidi, Touran Ahour   +2 more
doaj   +1 more source