Results 51 to 60 of about 90,388 (256)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Rural Cohesion: Collective Efficacy and Leadership in the Territorial Governance of Inclusion

Social Inclusion, 2020
This article is a comparative study of the contextual conditions for collective efficacy and territorial governance of social cohesion in two different rural localities: West Dorset in England and Lemvig in Denmark.
Anja Jørgensen, Mia Arp Fallov, Maria Casado-Diaz, Rob Atkinson   +3 more
doaj   +1 more source

Collective efficacy and arson: the case of Malmö [PDF]

Journal of Scandinavian Studies in Criminology and Crime Prevention, 2017
AbstractThe burning of cars and containers during social unrest has become a topic of both scholarly and public interest in Sweden over the past decade. Studies have suggested that social disorganization theory, or its modern expression collective efficacy, may be important for explaining why some neighbourhoods experience elevated levels of arson and ...
openaire   +3 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Message Persuasion in the Pandemic: U.S. and Chinese Respondents’ Reactions to Mediating Mechanisms of Efficacy

International Journal of Communication, 2022
In the context of the COVID-19 pandemic, this study derives from construal level theory and integrates self-construal, temporal framing, and narrative strategies to test the interactions between these variables.
He Gong, Miaohong Huang, Xiyuan Liu
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

What are the influences on teacher mobile technology self-efficacy within secondary school classrooms?

Journal of Open, Flexible and Distance Learning, 2016
As digital technologies develop and change, so do the ways these tools are integrated into classrooms. In particular, as mobile digital technologies become ubiquitous there is a need to investigate how teachers engage with these tools—both personally ...
Jo Tilton, Maggie Hartnett
doaj  

A study on the relationship between teachers’ job attitude, sense of efficacy and collective efficacy with their job commitment [PDF]

فصلنامه نوآوری‌های آموزشی, 2012
The aim of  the present research, was identifying the relationship between teachers’ job attitude, sense of efficacy, collective efficacy, and their job commitment.­ The research sample consisted of 220 guidance school teachers (120 female, 100 male) who
Elaheh Hejazi, Nahid Sadeghi, Sakineh Khatoon Khaki   +2 more
doaj  

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Being Positively Moved by Climate Protest Predicts Peaceful Collective Action

Global Environmental Psychology
People can be motivated to engage in collective action for climate protection because they are angry about an injustice or because they are emotionally moved by the idea that they can achieve something together. However, previous research on emotions and
Helen Landmann, Jascha Naumann
doaj   +1 more source