Results 41 to 50 of about 288,536 (295)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The Cost of Legal Restrictions on Experience Rating [PDF]

, 2020
We investigate the cost of legal restrictions on experience rating in auto and home insurance. The cost is an opportunity cost as experience rating can mitigate the problems associated with unobserved heterogeneity in claim risk, including mispriced ...
Barseghyan, Levon, Molinari, Francesca, Morris, Darcy Steeg, Teitelbaum, Joshua C.   +3 more
core   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Eagles enter rotor‐swept zones of wind turbines at rates that vary per turbine

Ecology and Evolution, 2021
There is increasing pressure on wind energy facilities to manage or mitigate for wildlife collisions. However, little information exists regarding spatial and temporal variation in collision rates, meaning that mitigation is most often a blanket ...
Christopher J. W. McClure, Brian W. Rolek, Melissa A. Braham, Tricia A. Miller, Adam E. Duerr, Jennifer D. McCabe, Leah Dunn, Todd E. Katzner   +7 more
doaj   +1 more source

Triton Field Trials: Promoting Consistent Environmental Monitoring Methodologies for Marine Energy Sites

Journal of Marine Science and Engineering, 2022
Uncertainty surrounding the potential environmental impacts of marine energy (ME) has resulted in extensive and expensive environmental monitoring requirements for ME deployments. Recently, there have been more ME deployments and associated environmental
Samantha L. Eaves, Garrett Staines, Genevra Harker-Klimeš, Margaret Pinza, Simon Geerlofs   +4 more
doaj   +1 more source

Prevention Strategies of Traumatic Brain Injury in Football Players [PDF]

, 2019
In this project, we study the effects of the impact angle during a helmet-to-helmet collision on stress distribution and deacceleration values of the brain tissue in efforts to reduce brain injuries for football players.
Baxter, Gary, Chou, Shih-Feng, Dong, Neil X., Hall, Zachary   +3 more
core   +1 more source

Prediction of Surface Topography Parameters in Direct Laser Interference Patterning of Stainless Steel Using Infrared Monitoring and Convolutional Neural Networks

Advanced Engineering Materials, EarlyView.
This study presents an infrared monitoring approach for direct laser interference patterning (DLIP) combined with a convolutional neural network (CNN). Thermal emission data captured during structuring are used to predict surface topography parameters.
Lukas Olawsky, Marcelo Sallese, Leander Kläber, Clemens Kuhn, Keming Du, Andrés Fabián Lasagni   +5 more
wiley   +1 more source

Influence of an Argon/Silane Atmosphere on the Temperature of a Thermal Plasma

Advanced Engineering Materials, EarlyView.
The influence of a silane‐doped argon atmosphere on the chemical composition and temperature of a thermal nontransferring argon plasma is investigated using optical emission spectroscopy. As a result of the high amount of free electrons resulting from the stepwise ionization and dissociation of the silane molecule, even a silane addition of 0.01 vol ...
Lena Kreie, David Kramer, Thomas Scheithauer, Hans Jürgen Maier, Thomas Hassel   +4 more
wiley   +1 more source

A Novel Method for Holistic Collision Risk Assessment in the Precautionary Area Using AIS Data

Systems
Ship collisions pose a significant threat to maritime safety, especially in congested precautionary areas with high vessel traffic density. Traditional collision risk assessment methods, such as distance to closest point of approach (DCPA) and time to ...
Yu Zhong, Hongzhu Zhou, Manel Grifoll, Agustí Martín, Yusheng Zhou, Jiao Liu, Pengjun Zheng   +6 more
doaj   +1 more source