Results 191 to 200 of about 1,279,401 (299)

Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder

Advanced Science, EarlyView.
NLRP3 inflammasome contributes to colitis and mood disorder. This study demonstrates that neddylation targets NLRP3 at K287, which hinders its interaction with K48‐linked ubiquitination E3 Trim31 and thereby stabilizes it. Neddylation blockade in myeloid cells and microglia mitigates DSS‐induced colitis and psychological stress‐induced anxiety‐like ...
Wenbin Gai, Mengyao Wu, Anbiao Wu, Zhaofei Jing, Zhenjie Ye, Jiayan Jin, Yaolin Zhang, Min Zhao, Genyu Liu, Xu Wang, Xiqin Yang, Jie Dong, Yunlu Xu, Jiyan Zhang   +13 more
wiley   +1 more source

Accelerating epigenetic age in right-sided colon cancer predicts a favorable outcome. [PDF]

Clin Epigenetics
Ye Q, Song P, Hu W, Zhang G.
europepmc   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Large bowel diverticulitis. [PDF]

Trauma Surg Acute Care Open
Vella MA, Foster SM.
europepmc   +1 more source

Regulating Tumor Metabolic Reprogramming with Biomimetic Co‐Delivery of Simvastatin and Kynureninase for Immunotherapy

Advanced Science, EarlyView.
After the intravenous injection of biomimetic and pH/ROS‐responsive PTSK@CRM, the nanoparticles can be accumulated in tumors and release Sim and KYNase to inhibit the tumor growth, regulate the metabolism of cholesterol and Kyn, and reverse the immunosuppressive tumor microenvironment.
Jiaxin Yin, Shengcai Yang, Zengguang Liu, Songchen Zhao, Siyu Sun, Ziling Liu, Quanshun Li   +6 more
wiley   +1 more source

Robotic, Laparoscopic, and Open Segmental Resection vs. Extended Colectomy for Transverse Colon and Splenic Flexure Cancers: A Systematic Review. [PDF]

Cureus
Arumugam S, Aggarwal S, Nagotu A, Atkin G, Gupta V.   +4 more
europepmc   +1 more source

Ribosome Homeostasis Regulated by SETD2 Preserves Intestinal Epithelial Barrier

Advanced Science, EarlyView.
SETD2 ablation causes dysregulation and recruitment defects of ribosome biogenesis factors, resulting in translational disorders of barrier maintenance genes, thereby compromising the intestinal barrier. These findings unveil a previously unappreciated role of ribosome biogenesis and translational regulation in preserving the intestinal epithelial ...
Hanyu Rao, Aiting Wang, Yue Xu, Wenxin Feng, Chunxiao Ma, Ziyi Wang, Wei Zhang, Wenqiong Su, Xiuying Xiao, Wei‐Qiang Gao, Xianting Ding, Li Li   +11 more
wiley   +1 more source

Case report: Minimally invasive management of synchronous early-stage ascending colon adenocarcinoma and type 1 papillary renal cell carcinoma presenting with severe anemia: a rare Chinese case. [PDF]

Front Oncol
Li J, Guo K, Yi L, Yuan C, Tang N, Wu S, Zhu Y, Tan Y, Wang Z, Yang W, Zhu Y, Tian Y, Wang S, Wang Q.   +13 more
europepmc   +1 more source

Proteogenomic characterization of human colon and rectal cancer

Nature, 2014
Bing Zhang, Jing Wang, Xiaojing Wang, Jing Zhu, Qi Liu, Zhiao Shi, Matthew Chambers, L. Zimmerman, Kent Shaddox, Sangtae Kim, Sherri R. Davies, Sean Wang, Pei Wang, C. Kinsinger, Robert C. Rivers, Henry Rodriguez, R. Townsend, Matthew J. C. Ellis, Steve Carr, David L. Tabb, R. Coffey, R. Slebos, Daniel C. Liebler, Steven A. Michael A. Karl R. Eric D. R. Philipp Karen A. Carr Gillette Klauser Kuhn Mani Mertins Ketchum Pa, Steve Carr, Michael A. Gillette, Karl R. Klauser, E. Kuhn, D. Mani, Philipp Mertins, K. Ketchum, A. Paulovich, Jeffrey R. Whiteaker, Nathan Edwards, P. McGarvey, Subha Madhavan, Pei Wang, Daniel W. Chan, A. Pandey, I. Shih, Hui Zhang, Zhen Zhang, Heng Zhu, Gordon A. Whiteley, S. Skates, F. White, D. Levine, Emily Boja, C. Kinsinger, Tara Hiltke, M. Mesri, Robert C. Rivers, Henry Rodriguez, K. Shaw, S. Stein, D. Fenyo, T. Liu, J. Mcdermott, S. Payne, K. Rodland, Richard D. Smith, P. Rudnick, Michael Snyder, Yingming Zhao, Xian Chen, D. Ransohoff, A. Hoofnagle, Daniel C. Liebler, M. Sanders, Zhiao Shi, R. Slebos, David L. Tabb, Bing Zhang, L. Zimmerman, Yue Wang, Sherri R. Davies, Li Ding, Matthew J. C. Ellis, R. Reid Townsend   +78 more
semanticscholar   +1 more source

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

Advanced Science, EarlyView.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu, Xinlin Xu, Yue Tong, Min Wang, Feng Ge, Min Wu, Yunlong Wang, Gang Chen, Xilan Yu, Shanshan Li   +9 more
wiley   +1 more source