Results 191 to 200 of about 897,221 (299)

Colorectal clear cell carcinoma: a literature review. [PDF]

J Med Case Rep
Salehi M, Rehman S, Jafari A, Yazdani MJ, Hashim S, Jafari HR.   +5 more
europepmc   +1 more source

Genetic and Functional Evidence Links Germline Biallelic Inactivating Variants in WWOX to Histological Mixed‐Type Thyroid Cancer

Advanced Science, EarlyView.
The role of germline WWOX loss‐of‐function variants in oncogenesis has remained poorly characterized. This study provides the first comprehensive genetic and functional evidence that such variants promote tumorigenesis through the disruption of multiple tumor‐suppressive mechanisms.
Xiaopeng Zhang, Jian Qi, Jialiang Wang, Zhipeng Wang, Yongguang Wang, Zongtao Hu, Ao Xu, Bo Hong, Hongzhi Wang   +8 more
wiley   +1 more source

Bidirectional microbial regulation by tyrosine metabolism enhances palmatine-mediated colitis protection. [PDF]

Gut Microbes
Sun D, Hua Z, Xiao Y, He D, Wu H, Lin X, Chen Q, Li Z, Hou Y.   +8 more
europepmc   +1 more source

CYP4X1/sEH‐Dependent Endocannabinoid Metabolism Drives Fibroblast‐Mediated Immunosuppression to Limit Immunotherapy in Colon Cancer

Advanced Science, EarlyView.
A proposed mechanism to explain the role of CYP4X1/sEH‐14,15‐EET‐EA system in colon cancer immune escape. 14,15‐EET‐EA, 14,15‐epoxyeicosatrienoic acid‐ethanolamide; sEH, soluble epoxide hydrolase; CYP4X1, cytochrome P450 4X1; GPR119, G‐protein coupled receptor 119; EGFR, epidermal growth factor receptor; Gs, Gαs subunit; cAMP, cyclic adenosine ...
Min Mo, Xuewei Chen, Yanzhuo Liu, Chenlong Wang, Xuehan Chen, Nan Zhang, Nan He, Ying Li, Jingyi Wang, Honglei Chen, Jing Yang   +10 more
wiley   +1 more source

A rare case of gastric cancer associated with gastric diverticulum. [PDF]

Medicine (Baltimore)
Cheng S, Lan W, Tang K, Zheng C.
europepmc   +1 more source

Oral Exposure to Food‐Grade Nanoparticles Poses a Risk of Alzheimer's Disease‐Like Symptoms by Triggering Autophagy Defects in Neurons

Advanced Science, EarlyView.
Three food‐grade nanomaterials induce dysregulated RyR‐Ca2+ signaling through epigenetic modifications. This dysregulation impairs the autophagic clearance process, ultimately leading to abnormal Aβ deposition and increase phosphorylated tau levels.
Jiaxin Shang, Jun Yan, He Lou, Xuanxi Jiang, Ziyue Wang, Yue Gao, Xiaohui Fan, Xiaoyan Lu   +7 more
wiley   +1 more source

Response to Comment on A Method for Continuous Surgeon Improvement in Rectal Cancer

Annals of Surgery Open
Davide Ferrari, MD, Tommaso Violante, MD, Amit Merchea, MD, Eric Dozois, MD, Robert A. Vierkant, MS, David W. Larson, MD, MBA   +5 more
doaj   +1 more source

Correction to: "Management of ulcerative colitis by dichloroacetate: impact on NFATC1/NLRP3/IL1B signaling based on bioinformatics analysis combined with in vivo experimental verification" [Inflammopharmacology (2024) 32:667-682]. [PDF]

Inflammopharmacology
Abdel-Razek E, Mahmoud HM, Azouz AA.
europepmc   +1 more source

Regulating Tumor Metabolic Reprogramming with Biomimetic Co‐Delivery of Simvastatin and Kynureninase for Immunotherapy

Advanced Science, EarlyView.
After the intravenous injection of biomimetic and pH/ROS‐responsive PTSK@CRM, the nanoparticles can be accumulated in tumors and release Sim and KYNase to inhibit the tumor growth, regulate the metabolism of cholesterol and Kyn, and reverse the immunosuppressive tumor microenvironment.
Jiaxin Yin, Shengcai Yang, Zengguang Liu, Songchen Zhao, Siyu Sun, Ziling Liu, Quanshun Li   +6 more
wiley   +1 more source

Correction: Harnessing ExDNA for precision Exatecan delivery in cancer: a novel antibody-drug conjugate approach. [PDF]

Mol Cancer
Ianniello Z, Lu H, Quijano E, Colón-Ríos DA, Rackear M, Bommireddy V, Ludwig DL, Shen Z, Glazer PM.   +8 more
europepmc   +1 more source