Results 241 to 250 of about 1,052,853 (316)

Transfer RNA‐Derived Small RNA‐5’tiRNAGln Drives HNRNPC Phase Separation to Promote Breast Cancer Bone Metastasis by Regulating IGF1R

Advanced Science, EarlyView.
This study reveals that 5'tiRNA‐Gln interacts with hnRNPC to promote IGF1R liquid‐liquid phase separation, which drives ERK1/2 signaling activation, EMT, and breast cancer bone metastasis. These findings highlight a novel mechanism of breast cancer bone metastasis and potential therapeutic target in metastatic breast cancer.
Bingnan Wang, Dongsong Liu, Xiaozhi Fan, Jiale Fan, Xuesi liu, Yu Wang, Zixin Wang, Mo Cheng, Ping Zhou, Wangjun Yan   +9 more
wiley   +1 more source

CXCL3 Antagonism Reverses Systemic Antitumor Immune Memory Impairment Associated With High Tumor Burden and Sensitizes Anti‐PD‐1 Therapy

Advanced Science, EarlyView.
This study reveals that large tumors secrete more chemokine CXCL3, which recruits immunosuppressive neutrophils to the periphery, thereby impairing the activation and memory of systemic tumor‑reactive CD8+ T cells. CXCL3 antagonism restores systemic immune memory and enhances the antitumor efficacy of anti‑PD‑1 therapy, offering a potential strategy to
Ji Wang, Xinyu Tang, Zeju Li, Qi Qi, Chang Sun, Wen Sun, Weiya Zhang, Yue Yin, Ya Deng, Peiwen Ling, Yifan Xu, Guangshun Sun, Yi Ren, Hong Pan, Shui Wang, Wenbin Zhou   +15 more
wiley   +1 more source

Rumen and colon-centered microbiota-liver interactions associated with bile acid-related metabolic regulation in sheep. [PDF]

PeerJ
Gao Y, Wang B.
europepmc   +1 more source

Gut Microbial Topology and Metabolic Signatures Associated With Colorectal Neoplasia

Advanced Science, EarlyView.
The gut microbiota organizes into two robust association patterns linked to colorectal neoplasia risk. Topological shifts in microbial networks are associated with metabolite alterations and may shape host responses during disease development. ABSTRACT Alterations of gut microbial communities impact health.
Kai Song, Youwen Qin, Jiahui Luo, Liping Liu, Chenyu Luo, Yinbin Qiu, Yiyi Zhong, Huanzi Zhong, Kui Wu, Meng Ni, Dong Wu, Min Dai, Shida Zhu, Hongda Chen   +13 more
wiley   +1 more source

Concurrent Intestinal Tuberculosis and Colon Cancer in a Young Patient: A Diagnostic Challenge. [PDF]

ACG Case Rep J
A A, Kini R, Karunakaran PK.
europepmc   +1 more source

Epithelial NF-κB shapes protective Treg cell responses to restrain intestinal inflammation. [PDF]

Nat Commun
Barleben L, Schneegans AJ, Uyar B, Bruneau A, Vasileva G, Flohr F, Kabrani E, Vasilakis T, Hammann L, Gebert P, Dietrich C, Bochow-Fitzner B, Arnold A, Sai S, Gröne F, Sander M, Conrad T, Gérard A, Piseddu I, Anz D, Jochum C, Akalin A, Hammerich L, Klose CSN, Tacke F, Di Virgilio M, Kolesnichenko M.   +26 more
europepmc   +1 more source