Results 231 to 240 of about 1,218,134 (318)

The crotonylation reader DPF2 promotes the development and progression of colon adenocarcinoma through cell-type-specific immune regulation and metabolic reprogramming. [PDF]

Front Pharmacol
Wang J, Zhou J, Liu L.
europepmc   +1 more source

Cobalt Single‐Atom Nanozyme for Enhanced Intestinal Radioprotection and Tumor Radiosensitization via Bidirectional ROS Modulation

Advanced Science, EarlyView.
Orally administered, pH‐responsive Co‐SAN exerts dual functions: in the alkaline intestinal milieu, it scavenges reactive oxygen species (ROS) and suppresses the PI3K/AKT pathway and NETs formation, thus providing radioprotection; whereas in the acidic tumor microenvironment, it generates ROS and alleviates hypoxia, thereby enhancing radiosensitization.
Shengqi Yin, Junjie Li, Yishu Zou, Yang Liu, Yilin Zheng, Lu Yu, Wanying Zheng, Yajun Zou, Zehui Zhang, Tao Li, Peiqun Yin, Jianlin Zhang, Yuen Wu, Yi Ding   +13 more
wiley   +1 more source

Outcomes of Subtotal Colectomy with Ileorectal Anastomosis and Intensive Endoscopic Surveillance in Familial Adenomatous Polyposis: A Case Series. [PDF]

Cancer Manag Res
Yang CH, Tsai HL, Chen YC, Chen PJ, Chang TK, Su WC, Huang CW, Wang JY.   +7 more
europepmc   +1 more source

Risk of Inflammatory Bowel Disease Following Hospital‐Treated Infections and Modulatory Role of Host Genetics to Support a Multi‐Hit Pathogenesis Model

Advanced Science, EarlyView.
Hospital‐treated infections are linked to increased risk of inflammatory bowel disease in a large prospective cohort. This risk differs by infection burden, time since infection, and host immune‐genetic susceptibility. The findings support a multi‐hit pathogenesis model in which severe infection and inherited susceptibility jointly shape inflammatory ...
Haiming Zhuang, Lintao Dan, Xin Xiang, Xixian Ruan, Shuai Yuan, Jialu Yao, Jiawei Geng, Jonas F. Ludvigsson, Tian Fu, Candida Abreu, Laurent Peyrin‐Biroulet, Xue Li, Yi Xiao, Fernando Magro, Xiaoyan Wang, Jing Sun, Jie Chen   +16 more
wiley   +1 more source

Successful treatment of non-occlusive mesenteric ischemia in a patient undergoing combined therapy with peritoneal dialysis and hemodialysis: a case report. [PDF]

CEN Case Rep
Hoshino T, Uchida T, Koizumi M, Kojima T, Yoshikawa N, Yamada M, Higuchi H, Sano T, Kawachi S, Oda T.   +9 more
europepmc   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Human colon organoid Transwell model for investigating epithelial growth and repair. [PDF]

NPJ Biomed Innov
Tong X, Holokai L, Keir M, Balazs M, Li J.   +4 more
europepmc   +1 more source

Ultrasonographic features of 5-aminosalicylic acid intolerance in pediatric ulcerative colitis. [PDF]

Clin Exp Pediatr
Murashige H, Sakata Y, Azuma Y, Hasegawa S.   +3 more
europepmc   +1 more source

Management of two extremely aggressive signet ring cell colon carcinoma: a case series. [PDF]

J Surg Case Rep
Dalir N, Parker GS, Masia RA, Torres P.
europepmc   +1 more source