Results 51 to 60 of about 1,397,746 (291)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

open access: yesMolecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster   +3 more
wiley   +1 more source

Remembering and belonging : colonial settlers in New Zealand museums : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Social Anthropology at Massey University [PDF]

open access: yes, 2007
This study approaches museums as socially constructed signifiers of group identities. Focusing specifically on museological representations of colonial settlers at museums and historical sites in New Zealand, I analyse how this group is constructed in ...
Wirick, Esther Lucia
core  

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

open access: yesMolecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu   +18 more
wiley   +1 more source

The Aden pivot? British counter-insurgency after Aden [PDF]

open access: yes, 2014
This article argues that the Aden Insurgency was a pivotal moment in the history of British counter-insurgency. We argue that it was in Aden where the newfound strength of human rights discourse, embodied in Amnesty International, and of anti-colonial ...
Dingli, Sophia, Kennedy, Caroline
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

La historia como realidad y ficción: los distintos mundos de El hombre en el castillo

open access: yesNorteamérica, 2018
Se analiza la serie televisiva de El hombre en el castillo, una ucronía inspirada en la novela homónima de ciencia ficción de Philip K. Dick, donde se plantea una historia alternativa en la que Alemania y Japón han ganado la segunda guerra mundial a los
Nelson Arteaga Botello
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

En una tierra inmensa y sin clérigos. La fundación del seminario del Tucumán, 1587-1611

open access: yesSecuencia, 2016
En este trabajo se estudia la creación del seminario conciliar de la diócesis del Tucumán. Un colegio muy distinto a los ordenados en el concilio de Trento, tanto por sus características, como porque su fundación formal tuvo por objetivo que la Compañía ...
Leticia Pérez Puente
doaj   +1 more source

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