Results 61 to 70 of about 1,397,746 (291)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

Is Video-Conferencing Helpful for Physical Education Classes in the New Normal? A PLS-SEM Analysis Adopting the Technology Acceptance Model

open access: yesJournal of Learning for Development
Research shows that videoconferencing tools can be used for delivering high-quality instruction in real-time to a large number of students simultaneously during and even in the aftermath of the pandemic.
Joseph Lobo   +3 more
doaj   +1 more source

Book Review Essay: The Mature Phase: Four Generations of Scholarship on Colonial Mesoamerica and New Spain [PDF]

open access: yes, 2018
This essay reviews the following works: Native Wills from the Colonial Americas: Dead Giveaways in a New World. Edited by Mark Christensen and Jonathan Truitt. Salt Lake City: University of Utah Press, 2016. Pp. vii + 276. $55.00 cloth.
Matthew, Laura E.
core   +1 more source

Book Review: \u3cem\u3eThe Language of Disenchantment: Protestant Literalism and Colonial Discourse in British India\u3c/em\u3e [PDF]

open access: yes, 2013
A review of The Language of Disenchantment: Protestant Literalism and Colonial Discourse in British India by Robert A ...
Gonsalves, Roselle M.
core   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Colonial Ideology, Colonial Sciences and Colonial Sociology in Belgium [PDF]

open access: yesThe American Sociologist, 2020
AbstractAt the turn of the twentieth century, Belgian sociology and Belgian colonialism in Congo developed into a small political and academic elite that shared the same ideological stances. Colonialism played a more significant role. Colonization provided a new stage for emerging disciplines such as geography and sociology – which played their part in
openaire   +1 more source

“¡España es también aquí!”: Nación e imaginario colonial en los cuentos de Emilia Pardo Bazán

open access: yesCastilla: Estudios de Literatura, 2018
En el contexto de la biopolítica imperialista del siglo XIX, la guerra en Cuba y Filipinas supuso para España el cuestionamiento definitivo de su vigor racial y un replanteamiento de su configuración nacional. Emilia Pardo Bazán fue una de las plumas que
Susana Bardavío Estevan
doaj   +1 more source

May it Please Your Honor : Letters of Petition as Historical Evidence in an African Colonial Context [PDF]

open access: yes, 2010
This paper presents some preliminary conclusions drawn from an ongoing project which aims to collect and collate letters of petitions in colonial Nigeria as primary source for historians and other scholars.
Korieh, Chima J.
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

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