Results 121 to 130 of about 1,115,426 (335)

Flexible Estimation of the Heterogeneous Non-Parametric Component in a Relative Survival Cure Model [PDF]

arXiv
Estimating the cure fraction in a diseased population, especially in the presence of competing mortality causes, is crucial for both patients and clinicians. It offers a valuable measure for monitoring and interpreting trends in disease outcomes. When information on the cause of death is unavailable or unreliable, the Relative Survival (RS) framework ...
arxiv  

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source

DomainScope: A disease network based on protein domain connections [PDF]

arXiv, 2019
Protein domains are highly conserved functional units of proteins. Because they carry functionally significant information, the majority of the coding disease variants are located on domains. Additionally, domains are specific units of the proteins that can be targeted for drug delivery purposes.
arxiv  

Epitope Mapping of Anti‐Neurofascin 155 Antibody in a Large Cohort of Autoimmune Nodopathy Patients

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune nodopathy (AN), a newly recognized disease entity, is an immune‐mediated polyneuropathy involving autoantibodies against cell adhesion molecules located in nodes of Ranvier and paranodal regions, such as neurofascin 186 (NF186) and neurofascin 155 (NF155). The present study aimed to identify the epitopes for autoantibodies
Amina A. Abdelhadi, Hidenori Ogata, Xu Zhang, Takumi Tashiro, Ryo Yamasaki, Jun‐ichi Kira, Noriko Isobe   +6 more
wiley   +1 more source

An application of medial limits to iterative functional equations [PDF]

arXiv, 2019
Assume that $(\Omega,\mathcal A,P)$ is a probability space, $f\colon[0,1] \times \Omega\to[0,1]$ is a function such that $f(0,\omega)=0$, $f(1,\omega)=1$ for every $\omega\in\Omega$, $g\colon[0,1]\to\mathbb R$ is a bounded function such that $g(0)=g(1)=0$, and $a,b\in\mathbb R$.
arxiv  

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

Effects of microgels fabricated by microfluidic on the stability, antioxidant, and immunoenhancing activities of aquatic protein

Journal of Future Foods
Aquatic products are considered a potential source of novel bioactive proteins, which are used as therapeutic drugs for the treatment of different diseases (such as oxidative stress, immunocompromised, and inflammation), as well as nutraceuticals and ...
Mengjun Wang, Yaolan Cheng, Xue Li, Linyu Nian, Biao Yuan, Shujie Cheng, Suilou Wang, Chongjiang Cao   +7 more
doaj  

On the existence of homoclinic type solutions of inhomogenous Lagrangian systems [PDF]

arXiv, 2017
We study the existence of homoclinic type solutions for second order Lagrangian systems of the type $\ddot{q}(t)-q(t)+a(t)\nabla G(q(t))=f(t)$, where $t\in\mathbb{R}$, $q\in\mathbb{R}^n$, $a\colon\mathbb{R}\to\mathbb{R}$ is a continuous positive bounded function, $G\colon\mathbb{R}^n\to\mathbb{R}$ is a $C^1$-smooth potential satisfying the Ambrosetti ...
arxiv  

A Novel Protein‐Polysaccharide Oral Nanoemulsion Targeting Activated Hepatic Stellate Cells to Enhance the Therapeutic Effect of Pirfenidone on Fibrosis After Transarterial Chemoembolization for Liver Cancer

Advanced Functional Materials, EarlyView.
Transarterial Chemoembolization (TACE) may aggravate liver fibrosis. In this study, a novel oral targeting nanoemulsion is fabricated to enhance the therapeutic effect of antifibrotic drug‐pirfenidone (PFD) on fibrosis after TACE. Studies have shown that PFD nanoemulsion can enhance the oral liver targeting effect of PFD, and effectively improve the ...
Zhimei Cheng, Shan Xu, Yi Lei, Huizhou He, Runbin Sun, Xingle Jin, Cheneryu Huang, Yuhao Zheng, Jianqing Peng, Lei Tang, Peng Luo, Yi Chen, Shuai Zhang   +12 more
wiley   +1 more source