Results 101 to 110 of about 9,470,889 (359)

POSSIBILITIES OF DYSBIOTIC CHANGES CORRECTION IN PATIENTS WITH JOINTS AND SPINE INJURIES AND INFLAMMATORY BOWEL DISEASES

open access: yesВісник проблем біології і медицини, 2020
The goal of our research was to study the efficiency of safe probiotic Bacillus clausii administration in correction of dysbiotic changes in patients with inflammatory bowel diseases when they also have extraintestinal joints and spine injuries.
Zhdan V. M.   +4 more
doaj   +1 more source

Nanomaterials and nanoparticles: Sources and toxicity [PDF]

open access: yesPublished in Biointerphases Vol. 2, issue 4 (2007) pages MR17 - MR71, 2008
This review is written with the goal of informing public health concerns related to nanoscience, while raising awareness of nanomaterials toxicity among scientists and manufacturers handling them. We show that humans have always been exposed to nanoparticles and dust from natural sources and human activities, the recent development of industry and ...
arxiv  

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

open access: yesMolecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park   +6 more
wiley   +1 more source

SURF-SVM Based Identification and Classification of Gastrointestinal Diseases in Wireless Capsule Endoscopy [PDF]

open access: yesarXiv, 2020
Endoscopy provides a major contribution to the diagnosis of the Gastrointestinal Tract (GIT) diseases. With Colon Endoscopy having its certain limitations, Wireless Capsule Endoscopy is gradually taking over it in the terms of ease and efficiency. WCE is performed with a miniature optical endoscope which is swallowed by the patient and transmits colour
arxiv  

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

Cluster detection and risk estimation for spatio-temporal health data [PDF]

open access: yesarXiv, 2014
In epidemiological disease mapping one aims to estimate the spatio-temporal pattern in disease risk and identify high-risk clusters, allowing health interventions to be appropriately targeted. Bayesian spatio-temporal models are used to estimate smoothed risk surfaces, but this is contrary to the aim of identifying groups of areal units that exhibit ...
arxiv  

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

[Computed tomography and magnetic resonance imaging of colonic diseases]. [PDF]

open access: yesRadiologie (Heidelb), 2023
Scharitzer M   +3 more
europepmc   +1 more source

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