Results 111 to 120 of about 9,470,889 (359)
Determining Health Utilities through Data Mining of Social Media [PDF]
arXiv, 2016 'Health utilities' measure patient preferences for perfect health compared to specific unhealthy states, such as asthma, a fractured hip, or colon cancer. When integrated over time, these estimations are called quality adjusted life years (QALYs). Until now, characterizing health utilities (HUs) required detailed patient interviews or written surveys ...
arxiv
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
Diverticular disease of the colon [PDF]
Postgraduate Medical Journal, 1968 T. L. Cleave, G. D. Campbell
+12 more sources
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Using infrared gas sensors in an in-vitro dynamic gut model for detecting short-chain fatty-acids: Technical Report [PDF]
arXiv, 2019 Short-chain fatty acids (SCFAs), including acetate, propionate and butyrate, are organic fatty-acids that are produced when indigested carbohydrates are fermented in the colon by gut-bacteria. Butyrate is especially considered a beneficial compound in relation to gut health and the maintenance of colonic homeostasis.
arxiv
Trypanosomiasis in the Absence of Tsetses, and a Human Disease possibly carried by Simulium in Kenya Colony [PDF]
, 1921 F. W. Dry
openalex +1 more source
Civilization and the colon: Constipation as "the disease of diseases"
Western Journal of Medicine, 2000 The publication in April 2000 of the results of a clinical trial that found high fibre cereals had no protective effect against colorectal adenomas stirred up considerable media attention and shook a cherished tenet of popular health culture.1 After all, boxes of All-Bran have been assuring us for nearly two decades that they contain “at last, some ...
openaire +5 more sources
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source