A Millennium Bug Still Bites Public Health - An Illustration Using Cancer Mortality [PDF]
arXiv, 2014 Accurate estimation of cancer mortality rates and the comparison across cancer sites, populations or time periods is crucial to public health, as identification of vulnerable groups who suffer the most from these diseases may lead to efficient cancer care and control with timely treatment.
arxiv
Zonal Colonic Aganglionosis, a Variant of Hirschsprung's Disease [PDF]
, 1972 A. G. MacIver, R. Whitehead
openalex +1 more source
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source
Autologous cell transplantation for treatment of colorectal aganglionosis in mice
Nature CommunicationsNeurointestinal diseases cause significant morbidity and effective treatments are lacking. This study aimes to test the feasibility of transplanting autologous enteric neural stem cells (ENSCs) to rescue the enteric nervous system (ENS) in a model of ...
Weikang Pan +10 more
doaj +1 more source
PharmaceuticalsBackground/Objectives: Oxidized low-density lipoprotein (ox-LDL) is a proinflammatory particle associated with various diseases and affects cell proliferation and viability in multiple cell types.
Eddy E. Gonzalez-Horta +10 more
doaj +1 more source
Evolutionary Genetic Engineering in the Indo-Pacific: Conservation, Humanitarian, and Social Issues [PDF]
arXiv, 2017 The Indo-Pacific region contains a unique mix of opportunities for the development and use of genetic-pest-management, gene-drive, and gene-drive-like technologies. Here I collectively refer to these technologies as Evolutionary Genetic Engineering (EGE).
arxiv
Effect of Methylcellulose on Rectal and Colonic Pressures in Treatment of Diverticular Disease [PDF]
, 1972 John Hodgson
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Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
wiley +1 more source
MugenNet: A Novel Combined Convolution Neural Network and Transformer Network with its Application for Colonic Polyp Image Segmentation [PDF]
arXivBiomedical image segmentation is a very important part in disease diagnosis. The term "colonic polyps" refers to polypoid lesions that occur on the surface of the colonic mucosa within the intestinal lumen. In clinical practice, early detection of polyps is conducted through colonoscopy examinations and biomedical image processing.
arxiv
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source