Results 71 to 80 of about 59,560 (374)

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Surgical outcomes and factors associated with postoperative complications of colorectal cancer in a Colombian Caribbean population: Results from a regional referral hospital

Cancer Reports, 2023
Introduction Colorectal cancer is the most common malignant neoplasm of the gastrointestinal tract. Its incidence and mortality vary markedly at a global level.
Edgar Ernesto Vergara Dagobeth, Gian Alberto Núñez Rojas, Juan Carlos Hoyos Valdelamar, Ivan David Lozada‐Martínez, Amileth Suarez Causado, Alexis Rafael Narvaez‐Rojas   +5 more
doaj   +1 more source

How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and men [PDF]

, 2005
Tumours in rodent and human colon share many histological and genetic features. To know if rodent models of colon carcinogenesis are good predictors of chemopreventive efficacy in humans, we made a meta-analysis of aspirin, beta-carotene, calcium, and ...
Adell-Carceller, Ahn, Alberts, Barbolt, Barbolt, Barnes, Barnes, Baron, Baron, Barsoum, Beaty, Behling, Belbraouet, Benamouzig, Bird, BonithonKopp, Bruce, Bull, Chiu, Chung, Clevers, Colacchio, Colnot, Corpet, Corpet, Craven, Cucherat, Davis, Denis E. Corpet, DeWind, Dorval, Drankhan, Fabrice Pierre, Femia, Fodde, Forman, Gescher, Gill, Green, Greenberg, Harris, Hawk, Hioki, Hofstad, Huerta, Imaida, Jacobs, Karkare, Kinzler, Kritchevsky, Laird, Li, MacLennan, Mahmoud, McIntosh, McKeown-Eyssen, McKeown-Eyssen, McSherry, Miliaras, Molck, Moser, Mutanen, Narayan, Nelson, Newmark, ObermuellerJevic, Orner, Oshima, Pence, Pence, Pence, Pence, Perkins, Pierre, Pierre, Pierre, Pound, Quilliot, Ranhotra, Reddy, Reddy, Reddy, Reichling, Reuter, Sandler, Sansom, Schatzkin, Shaukat, Sinkeldam, Sitrin, Takahashi, Takahashi, Takayama, Temple, Toth, Trinh, Tsukamoto, VinasSalas, Vogelstein, Wargovich, Watanabe, Wei, Wijnands, Williamson, Xing, Yamamoto, Yang, Yang, Yang, Yu   +109 more
core   +3 more sources

Distinct dysregulated pathways in sporadic and Lynch syndrome‐associated colorectal cancer offer insights for targeted treatment

FEBS Letters, EarlyView.
This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause, Musalula Sinkala, Raj Ramesar   +2 more
wiley   +1 more source

Intussusception Caused by Colon Cancer in Pregnancy

The Korean Journal of Gastroenterology, 2019
Intussusception is a common in pediatric age group. But it is rare in adults. And intussusception caused by tumor account for 1% of bowel obstructions in adult. Intussusception is an extremely rare cause of abdominal pain in pregnancy.
Kyungjoong Kim, Myungkwan Ko, Ho Chan Sim, Chang Lae Kim, Yeo Jin Jung, Tae Oh Kim   +5 more
doaj   +1 more source

Mucosubstances in neoplasms of the human colon and rectum [PDF]

Gut, 1971
The patterns of mucosubstances secreted in the normal human colon and rectum, in benign tumours, and in and around malignant tumours of the colon and rectum have been studied. Very little neutral mucosubstance was seen in normal specimens; the secretion in these was made up of sulphated and nonsulphated acid mucosubstances, with the former ...
openaire   +3 more sources

Immunoregulatory mechanisms of the arachidonic acid pathway in cancer

FEBS Letters, EarlyView.
The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine, Matteo Mucci, Antonio Recchiuti, Domenico Mattoscio   +3 more
wiley   +1 more source

A Case of Myeloid Sarcoma of Intestine

The Korean Journal of Gastroenterology, 2016
Myeloid sarcoma (MS) is an extramedullary involvement of immature myeloid proliferation. An isolated MS is defined as a myeloblastic tumor when it arises without any concomitant circulating disease.
Sung Won Lim, Hang Lak Lee, Kang Nyeong Lee, Dae Won Jun, In Young Kim, Eunjin Kim, Hyein Ahn, Chan Kum Park   +7 more
doaj   +1 more source

Perivascular epithelioid cell neoplasm of the colon

World Journal of Gastrointestinal Oncology, 2010
A 17-year-old female presented with rectal bleeding from an ulcerated sigmoid mass in 1994. Initial pathological evaluation revealed a rare clear cell neoplasm of the colon, possibly originating from kidneys, adrenals, lung or a gynecologic source as a metastatic lesion.
Hugh J Freeman, Doug L Webber
openaire   +3 more sources

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source