Results 91 to 100 of about 1,118,799 (244)
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Colony specificity in Botrylloides leachi (Savigny): preliminary reports
, 2000 A morphological and histochemical study of colony specificity in the compound ascidian Botrylloides leachi was undertaken. Preliminary results indicate that fusion occurs when genetically related colonies encounter, whereas subcuticular rejection is ...
BALLARIN, LORIANO +3 more
core +1 more source
Tumor Biology, 2018 Macrophage-colony stimulating factor, matrix metalloproteinase-9, and tissue inhibitor of metalloproteinase-1 may play an important role in malignant processes.
Monika Zajkowska +7 more
doaj +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Southern California Colony, Goshen, Tulare Co., California ...
, 1877 Broadside encouraging settlers to buy land in the Southern California Colony in Tulare County ...
California Immigrant Union
core
Ant Colony Optimisation – A Proposed Solution Framework for the Capacitated Facility Location Problem [PDF]
This thesis is a critical investigation into the development, application and evaluation of ant colony optimisation metaheuristics, with a view to solving a class of capacitated facility location problems. The study is comprised of three phases.
Venables, Harry
core +3 more sources
Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region
FEBS Open Bio, EarlyView.Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson +2 more
wiley +1 more source
Temperature as an early warning signal of honeybee colony failure
Ecological InformaticsHow to identify ecological systems at risk of failure is a central question of modern biology and agriculture. Due to human impacts and global change, there is a growing need for early warning signals that identify when a system is at risk of a state ...
Theotime Colin +5 more
doaj +1 more source