Results 81 to 90 of about 1,118,799 (244)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Automated sensing and splitting of stem cell colonies on microraft arrays

APL Bioengineering, 2019
Human induced pluripotent stem cells (hiPSCs) are widely used for disease modeling, tissue engineering, and clinical applications. Although the development of new disease-relevant or customized hiPSC lines is of high importance, current automated hiPSC ...
Matthew DiSalvo, Nicole M. Smiddy, Nancy L. Allbritton   +2 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

A novel selective medium Sucrose-Bacitracin agar 10 for accurate isolation and identification of Streptococcus mutans

BMC Oral Health
Background To develop and evaluate Sucrose-Bacitracin agar with 10% sucrose (SB-10), a novel selective medium designed to enhance the isolation and identification of Streptococcus mutans, a key cariogenic pathogen in dental caries.
Yuwen Fang, Qizhao Ma, Wei Zhao, Nian Liu, Lei Cheng, Jing Chen, Jing Zou   +6 more
doaj   +1 more source

Development of an Intelligent Visual SEA Detection Method for Salmonella

Shipin gongye ke-ji
Objective: This study aimed to develop a rapid and visual method for detecting Salmonella detection by integrating strand exchange amplification (SEA) with a smartphone-based application (APP).
Xiaotian SUN, Junying WANG, Yingting GONG, Jingnan MENG, Zhen LI, Yanyan ZHAO, Ligong ZHAI   +6 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Biochar application enhances ant (Formica japonica) ecological functions as indicated by their social behaviors

Biochar
Soil fauna activity is crucial for soil ecosystem functioning and health, but soil remediation techniques, such as biochar application, are seldom examined for their influence on soil fauna activity.
Sha Liu, Danling Xiong, Liang Zeng, Wei Du, Yang Liu, Christian E. W. Steinberg, Bo Pan, Shu Tao, Baoshan Xing   +8 more
doaj   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Newspaper: The Colony Herald, Volume 1, Number 3

, 1936
Third issue of The Colony Herald newspaper, published at the Dyess colony in Dyess, Arkansas. The headline announces the attendance of noted speakers to the upcoming anniversary of the colony's founding. The newspaper also contains international, state,
Williams, Oden S.; Newsom, Gene; Shaw, Helen; Dyess Colony, Inc.
core  

Symbiotic bacterial communities in rainforest fungus-farming ants: evidence for species and colony specificity. [PDF]

Sci Rep, 2020
Ronque MUV, Lyra ML, Migliorini GH, Bacci M, Oliveira PS.   +4 more
europepmc   +1 more source