Results 41 to 50 of about 1,592,768 (266)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Discussiones Mathematicae Graph Theory, 2015 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Wayne Goddard, Kirsti Wash, Honghai Xu
openaire +2 more sources
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Effect of Pluronic Introduction to Polycaprolactone Substrate on the Blend Hydrophilicity by Molecular Dynamic Simulation [PDF]
علوم و تکنولوژی پلیمر, 2016 Poly()ε-caprolactone) ()PCL) has been widely investigated for medical applications because of its good physicochemical properties; however hydrophobic nature of PCL has been a colossal obstacle toward achieving scaffolds which offer satisfactory cell ...
Mohammad Masoud Mirhosseini +2 more
doaj +1 more source
Polymer Testing, 2022 This investigation deals with the introduction of an efficient technique to acrylate almost all of the epoxide groups on epoxidized soybean oil (ESO) and synthesize a highly acrylated ESO (AESO) by using viscosity control agents (VCAs).
Sahar Abdollahi Baghban +2 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Color Constancy with Derivative Colors
CoRR, 2016 Information about the illuminant color is well contained in both achromatic regions and the specular components of highlight regions. In this paper, we propose a novel way to achieve color constancy by exploiting such clues. The key to our approach lies in the use of suitably extracted derivative colors, which are able to compute the illuminant color ...
Huan Lei, Guang Jiang, Long Quan
openaire +2 more sources