Results 131 to 140 of about 430,144 (311)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Influence of different disinfecting solutions on the color change of artificial irises used in ocular prostheses

, 2012
Making an artificial iris with an aesthetically acceptable color is an important aspect of ocular rehabilitation. This work evaluated the influence of different disinfecting solutions on changes to the color of artificial irises used in ocular prostheses.
Pesqueira, Aldieris Alves [UNESP], Goiato, Marcelo Coelho, Santos, Daniela Micheline dos, Pesqueira, Aldieris Alves, Santos, Daniela Micheline dos [UNESP], Goiato, Marcelo Coelho [UNESP], Haddad, Marcela Filié, Bannwart, Lisiane Cristina, Moreno, Amália   +8 more
core   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Microscopic and Color Changes in Direct Dental Restorative Composite Resins upon Immersion in Beverages: Characterization by Scanning Electron Microscopy (SEM) and Energy-Dispersive X-ray Spectroscopy (EDS)

Biomedicines
This study aimed to evaluate the staining sensitivity and surface changes in recent composite resins (Herculite Ultra XRV (Kerr, Bolzano, Italy), G-ænial A’CHORD (GC Corp, Tokyo, Japan), and Omnichroma (Yamaguchi, Japan)) when exposed to common beverages
Adrian Ioan Hajdu, Ramona Dumitrescu, Octavia Balean, Daniela Jumanca, Ruxandra Sava-Rosianu, Lucian Floare, Vanessa Bolchis, Titus Vlase, Atena Galuscan   +8 more
doaj   +1 more source

Color stability of natural colorant on blue pea flowers [PDF]

, 2010
The use of natural colorants is highly increasing in the food industry due to strong consumer demand for more natural products. On the other hand, synthetic colorant give harms to consumers that may affect health because of the unsuitable chemicals ...
Nornabilah, Mohd Hamdan
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Comparison of Color Stability and Surface Roughness of Interim Crowns Fabricated by Conventional, Milling and 3D Printing Methods

Clinical and Experimental Dental Research
Objectives Manufacturing temporary restorations is part of the treatment process in fixed prostheses, which is accomplished by different methods. The aim of this study is to compare the color stability and surface roughness of provisional crowns made by ...
Zahra Hashemzade, Mohammad Alihemmati, Seyed Mohammad Reza Hakimaneh, Sayed Shojaedin Shayegh, Mohammad Amin Bafandeh, Zahra Mohammadi   +5 more
doaj   +1 more source