Results 51 to 60 of about 2,925,624 (251)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Design of a crab-like bistable mechanism for nearly equal switching forces in forward and backward directions

open access: yes, 2018
A compliant bistable mechanism with a crab-like structure for nearly equal switching forces in the forward and backward directions is developed. It consists of four crab-leg-like beams and a shuttle mass.
Dung-An Wang   +2 more
core   +1 more source

Facial coloration tracks changes in women's estradiol [PDF]

open access: yes, 2015
Red facial coloration is an important social cue in many primate species, including humans. In such species, the vasodilatory effects of estradiol may cause red facial coloration to change systematically during females’ ovarian cycle.
Kandrik, Michal   +15 more
core   +1 more source

Weighted Gene Co-Expression Network Analysis of red body color formation of crimson snapper, Lutjanus erythropterus

open access: yesAquaculture Reports, 2023
Crimson snapper (Lutjanus erythropterus) is a highly valued economic fish species, with its red body color being a crucial economic characteristic. A systematic study of skin pigmentation could offer insights into the mechanism of red coloration. In this
Zhenmin Xu   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The Effect of Heat Treatment on Yellow-Green Beryl Color and Its Enhancement Mechanism

open access: yesCrystals
Beryl is classified as a cyclosilicate mineral, and its color is primarily determined by the type and oxidation state of trace elements. In this study, natural yellow-green beryl was used as the research subject, and heat treatment experiments were ...
Binru Hao, Shuxin Zhao, Qingfeng Guo
doaj   +1 more source

Evolution of female carotenoid coloration by sexual constraint in Carduelis finches

open access: yesBMC Evolutionary Biology, 2010
Background Females often express the same ornaments as males to a similar or lesser degree. Female ornaments can be adaptive, but little is known regarding their origins and mode of evolution.
Cardoso Gonçalo C, Mota Paulo
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

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