Results 41 to 50 of about 764,224 (312)

Low NLRP3 expression predicts a better prognosis of colorectal cancer [PDF]

, 2021
Feng Shi, Bo Wei, Tian Lan, Yang Xiao, Xin Quan, Jun Chen, Chong Zhao, Jinhang Gao   +7 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Low flow practice for laparoscopic colorectal surgery in pediatric patients

Bali Journal of Anesthesiology, 2018
Low flow anaesthesia and laparoscopic techniques in pediatric patients are two of many developments in the modern medical field. Both techniques were established to support environmentally friendly, safe, and comfortable anaesthesia practices for ...
Tjokorda Gde Agung Senapathi, Dewa Ayu Mas Shintya Dewi, Adinda Putra Pradhana, Andrian Yadikusumo, Alan F A. Sumanti   +4 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A rare case of Amyand’s hernia presenting as an enterocutaneous fistula

Journal of Surgical Case Reports, 2010
The finding of the vermiform appendix in an inguinal hernia has an incidence of approximately 1%. The condition is given the eponymous name Amyand’s hernia. However in just 0.08% the condition is complicated by an acute appendicitis.
L Flood, KH Chang, OJ McAnena
doaj  

Haemorrhoidal artery ligation compared to alternative surgical techniques for the treatment of grade II-IV haemorrhoids: A systematic review

Journal of Mind and Medical Sciences, 2023
Background. Haemorrhoidal disease is a common disorder in the Western World that commonly requires surgical treatment, but original open techniques were associated with significant complications and pain.
Dayna van de Hoef, Aisling Hogan
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Síndrome de Peutz - Jeghers: Seguimiento de una familia Syndrome of Peutz - Jeghers: Follow to family

Revista Colombiana de Cirugía, 2007
El síndrome Peutz - Jeghers es una enfermedad con pólipos del colon con un patrón autosómico dominante, su tipo histológico es hamartomatoso y aunque es muy rara la transformación maligna, se ha postulado una secuencia hamartoma - carcinoma.
María Helena Gaitán Buitrago, Alejandro Vélez Hoyos, Luis G Carvajal-Carmona, José Ignacio Restrepo R, Hernán Restrepo, Mario Hernán Ruiz Vélez, Fabián Juliao Baños, Rodrigo Castaño Llano   +7 more
doaj  

A Novel Experimental Model of Colorectal Endometriosis

Journal of Investigative Surgery, 2018
Purpose: Endometriosis is a disease that affects 6–10% of the female population, mainly women of reproductive age, and causes a variety of cyclic symptoms.
Anastasia Prodromidou, Vasilios Pergialiotis, Kitty Pavlakis, Laskarina Maria Korou, Maximos Frountzas, Dimitrios Dimitroulis, Georgios Vaos, Despina N. Perrea   +7 more
doaj   +1 more source

Clinical profile and colonoscopic findings in patients with lower gastrointestinal haemorrhage: a descriptive cross-sectional study

Asian Journal of Medical Sciences, 2020
Background: Most of the bleeding in the lower gastrointestinal tract are usually located in the rectum, colon and terminal ileum. Colonoscopy is an invasive procedure used for both diagnostic and therapeutic purposes for detection of lower ...
Subash Bhattarai , Ramesh Raj Acharya , Bishnu Jwarchan, Dipesh Karki   +3 more
doaj   +1 more source