Results 91 to 100 of about 5,474,833 (393)

Validation of a novel virtual reality simulation system with the focus on training for surgical dissection during laparoscopic sigmoid colectomy

BMC Surgery, 2022
Background Mastery of technical skills is one of the fundamental goals of surgical training for novices. Meanwhile, performing laparoscopic procedures requires exceptional surgical skills compared to open surgery.
Takashi Mori, Koji Ikeda, Nobuyoshi Takeshita, Koichi Teramura, Masaaki Ito   +4 more
doaj   +1 more source

In silico Identification of tipifarnib-like compounds by structure-based pharmacophore, virtual screening and molecular docking against K-Ras post-translation in colorectal cancer [PDF]

arXiv, 2023
Colorectal cancer is a public health problem.Approximately 30 to 50 \% of colorectal tumors are caused by mutations in the KRAS gene.These mutations induce uncontrolled proliferation.To date,There is no approved effective treatment for the mutated KRAS oncogene.Farnesyltransferase (FTI) inhibitors are considered a therapeutic target against the mutated
arxiv  

Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis

Nature Communications, 2020
Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded.
N. Papadimitriou, N. Dimou, K. Tsilidis, B. Banbury, Richard M. Martin, S. Lewis, N. Kazmi, T. Robinson, D. Albanes, K. Aleksandrova, S. Berndt, D. Timothy Bishop, H. Brenner, D. Buchanan, B. Bueno-de-Mesquita, P. Campbell, S. Castellví-Bel, A. Chan, J. Chang-Claude, M. Ellingjord-Dale, J. Figueiredo, S. Gallinger, G. Giles, E. Giovannucci, S. Gruber, A. Gsur, J. Hampe, H. Hampel, Sophia Harlid, T. Harrison, M. Hoffmeister, J. Hopper, L. Hsu, José María Huerta, J. Huyghe, M. Jenkins, T. Keku, T. Kühn, C. la Vecchia, L. Le Marchand, Christopher I. Li, Li Li, A. Lindblom, N. Lindor, B. Lynch, S. Markowitz, G. Masala, A. May, R. Milne, E. Monninkhof, Lorena Moreno, V. Moreno, P. Newcomb, K. Offit, Vittorio Perduca, P. Pharoah, E. Platz, J. Potter, G. Rennert, E. Riboli, María-José Sánchez, S. Schmit, R. Schoen, G. Severi, S. Sieri, M. Slattery, M. Song, C. Tangen, S. Thibodeau, R. Travis, A. Trichopoulou, C. Ulrich, F. V. van Duijnhoven, B. van Guelpen, P. Vodicka, E. White, A. Wolk, M. Woods, A. Wu, U. Peters, M. Gunter, N. Murphy   +81 more
semanticscholar   +1 more source

PIK3CA in Colorectal Cancer [PDF]

Frontiers in Oncology, 2014
PIK3CA, the catalytic subunit of PI3K, is mutated in many different tumors, including colorectal cancer (CRC). Mutations of PIK3CA have been reported in 10-20% of CRC, about 80% of mutations found in two hot spots in exon 9 and exon 20. In RAS wild-type CRC, PIK3CA mutations have been associated with a worse clinical outcome and with a negative ...
openaire   +4 more sources

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source

Multiple rapidly growing desmoid tumors that were difficult to distinguish from recurrence of rectal cancer

World Journal of Surgical Oncology, 2017
Background Intra-abdominal desmoid tumors are usually slow growing and solitary, but multifocal desmoid tumors develop on rare occasions. Diagnosing desmoid tumors before histological examination of a surgical biopsy is often difficult. In particular, if
Koki Nakanishi, Dai Shida, Shunsuke Tsukamoto, Hiroki Ochiai, Junichi Mazaki, Hirokazu Taniguchi, Yukihide Kanemitsu   +6 more
doaj   +1 more source

Deep Transfer Learning for Texture Classification in Colorectal Cancer Histology [PDF]

arXiv, 2020
Microscopic examination of tissues or histopathology is one of the diagnostic procedures for detecting colorectal cancer. The pathologist involved in such an examination usually identifies tissue type based on texture analysis, especially focusing on tumour-stroma ratio.
arxiv  

Temporal trends in mode, site and stage of presentation with the introduction of colorectal cancer screening: a decade of experience from the West of Scotland [PDF]

, 2015
background:  Population colorectal cancer screening programmes have been introduced to reduce cancer-specific mortality through the detection of early-stage disease.
A Downing, C von Wagner, CG Fraser, CS McArdle, CS Roxburgh, CS Roxburgh, D Mansouri, DC McMillan, EJ Morris, G Libby, H Gunnarsson, H Gunnarsson, HL Kelsall, JE Crozier, JH Anderson, JH Scholefield, JH Scholefield, JS Mandel, K Skala, KK Alexiusdottir, LH Sobin, O Kronborg, R Oliphant, R Oliphant, RJ Steele, RJ Steele, S Biondo, SJ Goodyear, SK Wong   +28 more
core   +2 more sources

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini, Ezgi Oner, Mark P. Ward, Sinead Hurley, Brian David Henderson, Faye Lewis, Stephen P. Finn, Gerard J. Fitzmaurice, John J. O'Leary, Sharon O'Toole, Lorraine O'Driscoll, Kathy Gately   +11 more
wiley   +1 more source

The effects of oxaliplatin-based adjuvant chemotherapy in high-risk stage II colon cancer with mismatch repair-deficient: a retrospective study

BMC Cancer
Background For high-risk stageIImismatch repair deficient (dMMR) colon cancers, the benefit of adjuvant chemotherapy remains debatable. The principal aim of this study was to evaluate the prognostic value of high-risk factors and the effect of ...
Leen Liao, Jinghua Tang, Zhigang Hong, Wu Jiang, Yuan Li, Lingheng Kong, Kai Han, Zhenlin Hou, Chenzhi Zhang, Chi Zhou, Linjie Zhang, Qiaoqi Sui, Binyi Xiao, Weijian Mei, Jiehai Yu, Wanjun Yang, Zhizhong Pan, Pei-Rong Ding   +17 more
doaj   +1 more source