Results 91 to 100 of about 1,124,548 (306)

Obesity-Induced Colorectal Cancer Is Driven by Caloric Silencing of the Guanylin-GUCY2C Paracrine Signaling Axis. [PDF]

, 2016
Obesity is a well-known risk factor for colorectal cancer but precisely how it influences risks of malignancy remains unclear. During colon cancer development in humans or animals, attenuation of the colonic cell surface receptor guanylyl cyclase C ...
Aing, Amanda, Blomain, Erik S., Blumberg, Richard S., Colon-Gonzalez, Francheska, Hyslop, Terry M., Kim, Gilbert W., Lin, Jieru E., Rock, Justin, Snook, Adam E., Stoecker, Brian, Tomczak, Michal, Waldman, Scott A., Zhan, Tingting   +12 more
core   +2 more sources

Osteoglycin (OGN) reverses epithelial to mesenchymal transition and invasiveness in colorectal cancer via EGFR/Akt pathway

Journal of Experimental & Clinical Cancer Research, 2018
Background Many types of cancers are devoid of the small leucine-rich proteoglycans: osteoglycin (OGN), but its role in tumorigenesis is poorly studied especially in colorectal cancers (CRC).
Xiang Hu, Ya-Qi Li, Qing-Guo Li, Yan-Lei Ma, Jun-Jie Peng, San-Jun Cai   +5 more
doaj   +1 more source

B7-H3 promotes colorectal cancer angiogenesis through activating the NF-κB pathway to induce VEGFA expression [PDF]

, 2020
Ruoqin Wang, Yanchao Ma, Shenghua Zhan, Guangbo Zhang, Lei Cao, Xueguang Zhang, Tongguo Shi, Weichang Chen   +7 more
openalex   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Preoperative systemic inflammation predicts postoperative infectious complications in patients undergoing curative resection for colorectal cancer [PDF]

, 2009
The presence of systemic inflammation before surgery, as evidenced by the glasgow prognostic score (mGPS), predicts poor long-term survival in colorectal cancer. The aim was to examine the relationship between the preoperative mGPS and the development of
CS McArdle, CS McArdle, D C McMillan, DC McMillan, DC McMillan, DC McMillan, DC McMillan, DC McMillan, DJ Hole, E F Leitch, EF Leitch, H Ytting, H Ytting, HJ Nielsen, J H Anderson, JE Crozier, JE Crozier, K Canna, L H Moyes, M Ishizuka, NP Rizk, P G Horgan, P Matthiessen, R F McKee, SF Khuri, T Nozoe, T Welsch, TW Du Clos, V Carstairs, WL Law   +29 more
core   +2 more sources

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Association between diverticulosis and colonic neoplastic lesions in individuals with a positive faecal immunochemical test [PDF]

, 2017
Background The association between diverticulosis and colonic neoplastic lesions has been suggested, but data in literature are conflicting. This study aimed to investigate such a relationship in patients participating in a colorectal cancer screening ...
Boggi, R., Hassan, C., Lorenzetti, R., Morini, S., Napoli, M., Ridola, L., Tomao, S., Zullo, A.   +7 more
core   +1 more source

CNOT7 facilitates radiation resistance in colorectal cancer through TRIM21/XRCC6-mediated non-homologous end joining repair

Cell Death and Disease
Radiotherapy is essential in the treatment of colorectal cancer (CRC), but the presence of drug resistance leads to poor prognosis for CRC patients. Identifying targets and mechanisms for regulating radiotherapy resistance has high clinical value.
Yien Li, Luying Cui, Shaoke Wang, Qunye Zhao, Fenqi Du, Songtao Du, Chenfeng Yu, Mingyu Xia, Shihui Zhao, Tian Luan, Yanlong Liu, Binbin Cui   +11 more
doaj   +1 more source

Resection of the urinary bladder for locally advanced colorectal cancer: a retrospective comparison of partial versus total cystectomy

BMC Surgery, 2019
Background The postoperative and survival outcomes of patients with primary advanced colorectal cancer who undergo partial versus total cystectomy have not been adequately compared, as studies of this topic are rare and comprise relatively small cohorts.
Akihiro Kondo, Takeshi Sasaki, Daichi Kitaguchi, Yuichiro Tsukada, Yuji Nishizawa, Masaaki Ito   +5 more
doaj   +1 more source

FOXA2 Suppression by TRIM36 Exerts Anti‐Tumor Role in Colorectal Cancer Via Inducing NRF2/GPX4‐Regulated Ferroptosis [PDF]

, 2023
Xin Liu, Chunli Yan, Chunxiao Chang, Fansong Meng, Shen Wen-jie, Song Wang, Yi Zhang   +6 more
openalex   +1 more source