Results 101 to 110 of about 5,289,946 (346)

Superior prognosis stratification for stage III colon cancer using log odds of positive lymph nodes (LODDS) compared to TNM stage classification: the Japanese study group for postoperative follow-up of colorectal cancer [PDF]

, 2020
Shimpei Ogawa, Michio Itabashi, Yoshiko Bamba, Masakazu Yamamoto, Kenichi Sugihara   +4 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Resection of the urinary bladder for locally advanced colorectal cancer: a retrospective comparison of partial versus total cystectomy

BMC Surgery, 2019
Background The postoperative and survival outcomes of patients with primary advanced colorectal cancer who undergo partial versus total cystectomy have not been adequately compared, as studies of this topic are rare and comprise relatively small cohorts.
Akihiro Kondo, Takeshi Sasaki, Daichi Kitaguchi, Yuichiro Tsukada, Yuji Nishizawa, Masaaki Ito   +5 more
doaj   +1 more source

Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability.

Journal of the National Cancer Institute, 2004
Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is a common autosomal dominant syndrome characterized by early age at onset, neoplastic lesions, and microsatellite instability (MSI).
A. Umar, C. Boland, J. Terdiman, S. Syngal, A. de la Chapelle, J. Rüschoff, R. Fishel, N. Lindor, L. Burgart, R. Hamelin, S. Hamilton, R. Hiatt, J. Jass, A. Lindblom, H. Lynch, P. Peltomaki, S. Ramsey, M. Rodriguez-Bigas, H. Vasen, E. Hawk, J. Barrett, A. Freedman, S. Srivastava   +22 more
semanticscholar   +1 more source

A Retrospective Analysis using Deep-Learning Models for Prediction of Survival Outcome and Benefit of Adjuvant Chemotherapy in Stage II/III Colorectal Cancer [PDF]

, 2021
Xingyu Li, Jitendra Jonnagaddala, Shuhua Yang, Hong Zhang, Xu Steven Xu   +4 more
openalex   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

CNOT7 facilitates radiation resistance in colorectal cancer through TRIM21/XRCC6-mediated non-homologous end joining repair

Cell Death and Disease
Radiotherapy is essential in the treatment of colorectal cancer (CRC), but the presence of drug resistance leads to poor prognosis for CRC patients. Identifying targets and mechanisms for regulating radiotherapy resistance has high clinical value.
Yien Li, Luying Cui, Shaoke Wang, Qunye Zhao, Fenqi Du, Songtao Du, Chenfeng Yu, Mingyu Xia, Shihui Zhao, Tian Luan, Yanlong Liu, Binbin Cui   +11 more
doaj   +1 more source

Osteoglycin (OGN) reverses epithelial to mesenchymal transition and invasiveness in colorectal cancer via EGFR/Akt pathway

Journal of Experimental & Clinical Cancer Research, 2018
Background Many types of cancers are devoid of the small leucine-rich proteoglycans: osteoglycin (OGN), but its role in tumorigenesis is poorly studied especially in colorectal cancers (CRC).
Xiang Hu, Ya-Qi Li, Qing-Guo Li, Yan-Lei Ma, Jun-Jie Peng, San-Jun Cai   +5 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer

Nature Medicine, 2019
Association studies have linked microbiome alterations with many human diseases. However, they have not always reported consistent results, thereby necessitating cross-study comparisons.
J. Wirbel, P. Pyl, E. Kartal, Konrad Zych, A. Kashani, A. Milanese, J. S. Fleck, A. Voigt, A. Pallejà, R. Ponnudurai, S. Sunagawa, Luis Pedro Coelho, P. Schrotz-King, E. Vogtmann, N. Habermann, E. Niméus, A. M. Thomas, P. Manghi, S. Gandini, D. Serrano, Sayaka Mizutani, H. Shiroma, Satoshi Shiba, T. Shibata, S. Yachida, Takuji Yamada, L. Waldron, A. Naccarati, N. Segata, R. Sinha, C. Ulrich, H. Brenner, Manimozhiyan Arumugam, P. Bork, G. Zeller   +34 more
semanticscholar   +1 more source