Results 101 to 110 of about 5,332,530 (372)

Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer.

New England Journal of Medicine, 2009
BACKGROUND We investigated the efficacy of cetuximab plus irinotecan, fluorouracil, and leucovorin (FOLFIRI) as first-line treatment for metastatic colorectal cancer and sought associations between the mutation status of the KRAS gene in tumors and ...
E. Van Cutsem, C. Köhne, E. Hitre, J. Zaluski, Chung-Rong Chang Chien, A. Makhson, G. D'Haens, T. Pintér, R. Lim, G. Bodoky, J. Roh, G. Folprecht, P. Ruff, C. Stroh, S. Tejpar, M. Schlichting, J. Nippgen, P. Rougier   +17 more
semanticscholar   +1 more source

Multiple rapidly growing desmoid tumors that were difficult to distinguish from recurrence of rectal cancer

World Journal of Surgical Oncology, 2017
Background Intra-abdominal desmoid tumors are usually slow growing and solitary, but multifocal desmoid tumors develop on rare occasions. Diagnosing desmoid tumors before histological examination of a surgical biopsy is often difficult. In particular, if
Koki Nakanishi, Dai Shida, Shunsuke Tsukamoto, Hiroki Ochiai, Junichi Mazaki, Hirokazu Taniguchi, Yukihide Kanemitsu   +6 more
doaj   +1 more source

CRISPR Knockout of the HuR Gene Causes a Xenograft Lethal Phenotype. [PDF]

, 2017
Pancreatic ductal adenocarcinoma (PDA) is the third leading cause of cancer-related deaths in the United States, whereas colorectal cancer is the third most common cancer.
Brody, Jonathan, Campbell, Paul M., Chand, Saswati N., Cheung, Edwin C,, Dixon, Dan A., Goetz, Austin, Lal, Shruti, Londin, Eric, Lowder, Cinthya Y., Mambelli-Lisboa, Nicole C., Nevler, Avinoam, Preet, Ranjan, Romeo, Carmella, Stout, Matthew C., Winter, Jordan M., Yeo, Charles, Zarei, Mahsa   +16 more
core   +1 more source

Estradiol regulates miR-135b and mismatch repair gene expressions via estrogen receptor-β in colorectal cells. [PDF]

, 2012
Estrogen has anti-colorectal cancer effects which are thought to be mediated by mismatch repair gene (MMR) activity. Estrogen receptor (ER) expression is associated with microRNA (miRNA) expression in ER-positive tumors.
Fu, Lei, He, Yu-qi, Jin, Peng, Ling, Xian-long, Rao, Jianyu, Sheng, Jian-qiu, Yen, Lawrence   +6 more
core   +1 more source

Colorectal cancer [PDF]

BMJ, 2013
This is the final version of the article. Available from the publisher via the DOI in this record. ; This is one of a series of occasional articles highlighting conditions that may be more common than many doctors realise or may be missed at first presentation.
Hamilton, W, Coleman, MG, Rubin, G
openaire   +4 more sources

Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance

Molecular Oncology, EarlyView.
In this research, we analyzed the relationship between gut microbiota and tumor. We discovered that both subcutaneous and metastatic tumors would alter the composition and metabolic function of gut microbiota. Meanwhile, fecal microbiota transplantation also indicated the anti‐tumor role of the gut microbiota, revealing the crosstalk between tumor and ...
Siyuan Zhang, Haimei Wen, Ying Chen, Jingya Ning, Di Hu, Yujiao Dong, Chenyu Yao, Bo Yuan, Shuanying Yang   +8 more
wiley   +1 more source

The PTTG1/VASP axis promotes oral squamous cell carcinoma metastasis by modulating focal adhesion and actin filaments

Molecular Oncology, EarlyView.
VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park, Sang Shin Lee, Shihyun Kim, Yeonjun Lee, Gyeonwon Park, Jung Oh Kim, Jongho Choi   +6 more
wiley   +1 more source

Temporal trends in mode, site and stage of presentation with the introduction of colorectal cancer screening: a decade of experience from the West of Scotland [PDF]

, 2015
background:  Population colorectal cancer screening programmes have been introduced to reduce cancer-specific mortality through the detection of early-stage disease.
A Downing, C von Wagner, CG Fraser, CS McArdle, CS Roxburgh, CS Roxburgh, D Mansouri, DC McMillan, EJ Morris, G Libby, H Gunnarsson, H Gunnarsson, HL Kelsall, JE Crozier, JH Anderson, JH Scholefield, JH Scholefield, JS Mandel, K Skala, KK Alexiusdottir, LH Sobin, O Kronborg, R Oliphant, R Oliphant, RJ Steele, RJ Steele, S Biondo, SJ Goodyear, SK Wong   +28 more
core   +2 more sources

Chemoprevention of colorectal cancer [PDF]

The International Journal of Biological Markers, 2003
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Biasco G., Di Marco M., Pantaleo M. A.
openaire   +3 more sources

NanoCMSer: a consensus molecular subtype stratification tool for fresh‐frozen and paraffin‐embedded colorectal cancer samples

Molecular Oncology, EarlyView.
Consensus molecular subtypes (CMS1‐4) have been identified to study colorectal cancer heterogeneity and serve as potential biomarkers. In this study, we developed and evaluated NanoCMSer, a NanoString‐based classifier using 55 genes, optimized for FF and FFPE to facilitate the clinical evaluation of CMS subtyping.
Arezo Torang, Simone van de Weerd, Veerle Lammers, Sander van Hooff, Inge van den Berg, Saskia van den Bergh, Miriam Koopman, Jan N. IJzermans, Jeanine M. L. Roodhart, Jan Koster, Jan Paul Medema   +10 more
wiley   +1 more source