Results 281 to 290 of about 5,474,833 (393)

Self‐Adjusting Engineered Probiotic for Targeted Tumor Colonization and Local Therapeutics Delivery

open access: yesAdvanced Science, EarlyView.
Zou et al. developed an engineered strain of Escherichia coli Nissle 1917 with precise targeting abilities for colonization and on‐demand payload release. The engineered probiotic survives and embolizes tumors only in the presence of more than 5 mM L‐lactate. Furthermore, the introduction of an α‐hemolysin circuit enhances its anti‐tumor effect.
Zhen‐Ping Zou   +8 more
wiley   +1 more source

Identification of progression related LncRNAs in colorectal cancer aggressiveness. [PDF]

open access: yesSci Rep
Xi W   +7 more
europepmc   +1 more source

Colonic Submucosa Targeted Delivery of Probiotic and Rhein for Ulcerative Colitis Treatment

open access: yesAdvanced Science, EarlyView.
A novel orally drug‐probiotic co‐delivery system designated as Rh‐YBS for UC treatment, which highlights three innovations: (i) YPs involves colonic submucosa delivery via M cells; (ii) Rh (drug) promotes the colonization and growth of BS (probiotic) in the colon.
Lingqiang Li   +21 more
wiley   +1 more source

Diet, faecal pH and colorectal cancer

open access: green, 1983
W. van Dokkum   +4 more
openalex   +1 more source

β‐Glucuronidase‐Expressing Lactobacillus reuteri Triggers Irinotecan Enterotoxicity Through Depleting the Regenerative Epithelial Stem/Progenitor Pool

open access: yesAdvanced Science, EarlyView.
XLP mitigated CPT11 mucositis by suppressing GUS‐expressing microbes, notably L. reuteri, and diminishing bacterial GUS activity, consequently reducing SN38 accumulation to protect the intestinal epithelium. This preservation of the mucosal stem cell niche enabled rapid regeneration of secretory lineages such as mucin‐producing goblet cells, which ...
Bei Yue   +15 more
wiley   +1 more source

Could the HALP score indicate poor prognosis in colorectal cancer patients? [PDF]

open access: yesTurk J Surg
Çağlıyan Ö   +7 more
europepmc   +1 more source

Meisoindigo Acts as a Molecular Glue to Target PKMYT1 for Degradation in Chronic Myeloid Leukemia Therapy

open access: yesAdvanced Science, EarlyView.
Meisoindigo targets PKMYT1 for degradation by acting as a molecular glue that enhances PKMYT1‐TRIM25 interaction, leading to K48‐linked ubiquitination and subsequent proteasomal degradation, thereby exerting therapeutic effects in chronic myeloid leukemia.
Zhao‐Xin Zhang   +10 more
wiley   +1 more source

Progress on the mechanism of intestinal microbiota against colorectal cancer. [PDF]

open access: yesFront Cell Infect Microbiol
Xing G, Cui Y, Guo Z, Han B, Zhao G.
europepmc   +1 more source

Home - About - Disclaimer - Privacy