Results 171 to 180 of about 68,962 (266)

Interventional Radiotherapy (Brachytherapy) Combined with Systemic Treatment-The Influence of RAS Gene Mutations and Combined Therapy on the Results and Toxicity of Colorectal Cancer Liver Metastases. [PDF]

Cancers (Basel)
Cisek P, Kozłowska A, Grzybowska-Szatkowska L.   +2 more
europepmc   +1 more source

Single‐Cell Profiling Reveals Distinct Immune Hallmarks in Untreated Primary Colorectal and Liver Metastasis Cancers

Chronic Diseases and Translational Medicine, EarlyView.
Features the major cell type compositions among colon and liver metastasis. (A) The study design for single‐cell data analysis. (B) The annotated major cell types. Each type was labeled with a special color. (C) Dot plot of canonical marker genes for major cell types. (D) Bar plot of the percentage for each cell type in individuals. (E) Bar plot of the
Zhixun Zhao, Haipeng Chen, Xu Guan, Zheng Jiang, Zheng Liu, Ming Yang, Hengchang Liu, Tianli Chen, Shuangmei Zou, Yibo Gao, Xishan Wang   +10 more
wiley   +1 more source

ASO Author Reflections: Optimizing the Dose of Floxuridine for the Adjuvant Treatment of Resected Colorectal Cancer Liver Metastases. [PDF]

Ann Surg Oncol
Labadie KP, Melstrom LG.
europepmc   +1 more source

Chemotherapeutic Potential of Fluorouracil‐Platinum (IV) Prodrugs Against Cisplatin‐Resistant Colorectal Cancer Cells

Chemistry – A European Journal, EarlyView.
ABSTRACT Fluorouracil‐platinum(IV) prodrugs represent a novel class of multimechanistic chemotherapeutics with enhanced anticancer potential. The prodrugs PtIVP‐5FUMeOBut and PtIV56‐5FUMeOBut were actualized by derivatising the clinical drug 5‐fluorouracil (5FU) and coordinating it to platinum(IV) complexes, leveraging the established cytotoxicity of ...
Maria George Elias, Aleen Khoury, Shadma Fatima, Timothy J. Mann, Shawan Karan, Meena Mikhael, Paul de Souza, Christopher P. Gordon, Kieran F. Scott, Janice R. Aldrich‐Wright   +9 more
wiley   +1 more source

Combining cell-free DNA fragmentomes and total tumour volume improves prognostication and tumour response evaluation in patients with colorectal cancer liver metastases. [PDF]

EBioMedicine
Crnovrsanin N, Zeeuw JM, Ali M, Kemna R, Alipanahi B, Lumbard K, Skidmore ZL, Rinaldi L, van 't Erve I, Wesdorp NJ, Huiskens J, van Steijn D, van Waesberghe JH, van den Bergh J, Nota I, Moos S, Bond MJG, Meiqari L, Huitink I, Giovannetti E, Stoker J, Verpalen I, van den Broek D, Meijer GA, Swijnenburg RJ, Punt CJA, Scharpf RB, Leal A, Dracopoli NC, Velculescu VE, Kok NFM, Kazemier G, Fijneman RJA.   +32 more
europepmc   +1 more source

Living Microbial Drugs

Chemistry – A European Journal, EarlyView.
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik, Nazlıcan Tunç, Senem Şen, Urartu Özgür Şafak Şeker   +3 more
wiley   +1 more source

"Winning" with laparoscopic liver resection for colorectal cancer liver metastases (CRLM). [PDF]

Hepatobiliary Surg Nutr
Schmitz R, Tohme ST, Geller DA.
europepmc   +1 more source

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

Cancer Nexus, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang, Chongchong Gao, Rui Jiang, Zijian Wu, Jian Bai   +4 more
wiley   +1 more source

Tissue-specific antitumor NK cell subsets identified in colorectal cancer liver metastases express candidate therapeutic targets. [PDF]

J Clin Invest
Mikulak J, Supino D, Marzano P, Terzoli S, Carriero R, Cazzetta V, Piazza R, Bruni E, Kunderfranco P, Donato A, Mapelli SN, Garuti R, Carnevale S, Scavello F, Magrini E, Zeleznjak J, Peano C, Donadon M, Costa G, Torzilli G, Mantovani A, Garlanda C, Mavilio D.   +22 more
europepmc   +1 more source

Recent Perspectives on Phytochemical Profile, Pharmacological Activities, and Industrial Applications of Guava (Psidium guajava)

Food Safety and Health, EarlyView.
Psidium guajava leaves contain potent bioactive compounds like quercetin, myricetin, and triterpenoids that show antioxidant, antidiabetic, anti‐inflammatory, and anticancer effects. They act by modulating NF‐κB, PPARγ, and α‐glucosidase and by inducing apoptosis and cell cycle arrest.
Muhammad Waqar, Sehrish Jabbar, Qudrat Ullah, Farhang Hameed Awlqadr, Muhammad Tayyab Arshad, Md. Sakhawot Hossain, Sammra Maqsood, Ali Ikram, Ammar Ahmad Khan, Worawan Panpipat, Manat Chaijan   +10 more
wiley   +1 more source