Results 1 to 10 of about 144,199 (118)

Liver microenvironment-driven immunosuppressive niche in colorectal cancer liver metastasis and its therapeutic remodeling [PDF]

Frontiers in Immunology
Colorectal cancer liver metastasis is the most frequent and clinically important pattern of distant spread in colorectal cancer and remains a major determinant of poor prognosis and treatment failure.
Zijing Liu, Jia Liu, Shengshan Xu, Yumin Zhong, Ke-Jie He, Zhuming Lu, Youbin Zheng, Yi Zhang, Qian Guo, Hongyu Chu   +9 more
doaj   +2 more sources

Proteomic landscape of colorectal cancer liver metastasis [PDF]

Translational Oncology
Background: Colorectal cancer metastasis, especially liver metastasis, is characterized by significant intricate diversity and remains a major contributor to patient mortality.
Ju Wu, Linlin Liu, Yaoyuan Chang, Xiaoyu Duan, Xi Chen, He Li, Zheng Wang, Lianyi Guo, Jiajun Yin   +8 more
doaj   +2 more sources

A multidimensional integration analysis reveals potential bridging targets in the process of colorectal cancer liver metastasis. [PDF]

PLoS ONE, 2017
Approximately 9% of cancer-related deaths are caused by colorectal cancer. Liver metastasis is a major factor for the high colorectal cancer mortality rate.
Bo Gao, Tian Yu, Dongbo Xue, Boshi Sun, Qin Shao, Hani Choudhry, Victoria Marcus, Jiannis Ragoussis, Yuguo Zhang, Weihui Zhang, Zu-Hua Gao   +10 more
doaj   +1 more source

CircNOLC1 Promotes Colorectal Cancer Liver Metastasis by Interacting with AZGP1 and Sponging miR‐212‐5p to Regulate Reprogramming of the Oxidative Pentose Phosphate Pathway

Advanced Science, 2023
Liver metastasis is a common cause of death in progressive colorectal cancer patients, but the molecular mechanisms remain unclear. Here, it is reported that a conserved and oxidative pentose phosphate pathway‐associated circular RNA, circNOLC1, plays a ...
Menglang Yuan, Xinsheng Zhang, Fangxia Yue, Feifan Zhang, Sufen Jiang, Xu Zhou, Jinjuan Lv, Zhenyu Zhang, Yuzhu Sun, Zihao Chen, Han Wu, Xiaoqian Liu, Xiaoqi Yu, Bowen Wei, Kexin Jiang, Fang Lin, Yunfei Zuo, Shuangyi Ren   +17 more
doaj   +1 more source

Effect of Chronic Psychological Stress on Liver Metastasis of Colon Cancer in Mice. [PDF]

PLoS ONE, 2015
Metastasis to the liver is a main factor in colorectal cancer mortality. Previous studies suggest that chronic psychological stress is important in cancer progression, but its effect on liver metastasis has not been investigated.
Lu Zhao, Jianhua Xu, Fang Liang, Ao Li, Yong Zhang, Jue Sun   +5 more
doaj   +1 more source

Multi-Omics Analysis of the Tumor Microenvironment in Liver Metastasis of Colorectal Cancer Identified FJX1 as a Novel Biomarker

Frontiers in Genetics, 2022
Colorectal cancer incidence and mortality have increased in recent years, with more than half of patients who died of colorectal cancer developing liver metastases.
Junwei Zou, Hesong Zhang, Yong Huang, Wenjing Xu, Yujin Huang, Siyuan Zuo, Zhenhan Li, Hailang Zhou   +7 more
doaj   +1 more source

R1 Classic and Combined Approaches in Surgical Strategies for Management of Synchronous Colorectal Liver Metastasis [PDF]

Minia Journal of Medical Research, 2023
Background: Liver is the most common target organ of metastasis from colorectal cancer. Surgery is the best treatment for patient of colorectal liver metastasis to achieve long term survival or even complete cure, 5-year survival rate after surgery is ...
Ahmed Elsebaey, Abubakr Mohieldin, Ashraf Mohamed, Mohammad Elian   +3 more
doaj   +1 more source

A prospective, single-centre, randomized, double-blind controlled study protocol to study whether long-term oral metronidazole can effectively reduce the incidence of postoperative liver metastasis in patients with colorectal cancer

Trials, 2023
Introduction Fifteen to 25% of patients with colorectal cancer have combined liver metastases at the time of diagnosis, whereas an additional 15 to 25% will develop liver metastases after curative resection of primary colorectal cancer, with the vast ...
Rui Qi Gao, Zhen Chang Mo, Hai Kun Zhou, Peng Fei Yu, Wei Dong Wang, Dan Hong Dong, Xi Sheng Yang, Xiao Hua Li, Gang Ji   +8 more
doaj   +1 more source

Exosomal lncRNA PCAT1 Promotes Tumor Circulating Cell-Mediated Colorectal Cancer Liver Metastasis by Regulating the Activity of the miR-329-3p/Netrin-1-CD146 Complex

Journal of Immunology Research, 2022
Objective. This study explored the colorectal cancer exosome lncRNA prostate cancer associated transcript 1– (PCAT1) mediated circulating tumors and the mechanism of cell colorectal cancer liver metastasis. Methods.
Xingbao Fang, Yongping Xu, Kezhi Li, Peiwan Liu, Hong Zhang, Yang Jiang, Jianwei Tang, Yuehong Li   +7 more
doaj   +1 more source

The role of microRNAs in colorectal liver metastasis: Important participants and potential clinical significances

Tumor Biology, 2017
Colorectal cancer is one of the most common cancers in the world, and liver metastasis is the leading direct cause of cancer-related deaths in colorectal cancer.
Dongxu Wang, Jie Liu, Tingting Huo, Yaowen Tian, Lei Zhao   +4 more
doaj   +1 more source