Results 41 to 50 of about 4,253,992 (294)

Long term outcomes of simultaneous laparoscopic versus open resection for colorectal cancer with synchronous liver metastases

Asian Journal of Surgery, 2019
Summary: Background/Objective: Because of the advancements in the surgical techniques of liver resection and improvements in anesthesia and postoperative critical care, the simultaneous resection of synchronous colorectal cancer with liver metastasis ...
Ying-Wei Chen, Ming-Te Huang, Tung-Cheng Chang   +2 more
doaj   +1 more source

ANALYSIS OF COLORECTAL CANCERS WITH LIVER METASTASIS

The journal of the Japanese Practical Surgeon Society, 1991
Among 371 patients with colorectal cancer experienced at our department from 1973 to 1989, fifty-seven with synchronous liver metastasis and 17 with metachronous ones whose lesions, namely, were found postoperatively, were subjected to clinicopathological analysis to clarify characteristicts of the liver metastasis colorectal cancer. The patients group
MADOKORO, Setsuo, KUMASHIRO, Ryunosuke, MAEKAWA, Takafumi, TESHIMA, Koichi, HIDESHIMA, Teru, IKENAGA, Hidetsune, TSUTSUMI, Shinichiro, YAMASAKI, Shigemichi, YOSHITAKE, Hiroaki, SANO, Chiaki, NUTSUKA, Sadamitsu, KAWAHIRA, Kouzaburou   +11 more
openaire   +2 more sources

Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer [PDF]

, 2011
: BACKGROUND: Structural rearrangements form a major class of somatic variation in cancer genomes. Local chromosome shattering, termed chromothripsis, is a mechanism proposed to be the cause of clustered chromosomal rearrangements and was recently ...
Marlous Hoogstraat, Lieshout, S., van, Stef van Lieshout, Ivo Renkens, Marco Koudijs, Hoogstraat, M., Isaac J Nijman, Edwin Cuppen, Ruben van 't Slot, José van de Belt, Masoumeh Tavakoli-Yaraki, Wijnand Roessingh, Vermaat, J.S., Slot, R., van 't, Nijman, I.J., Kloosterman, W.P., Emile Voest, Renkens, I., Oscar Paling, Joost S Vermaat, Wigard P Kloosterman, Belt, J., van de, Roessingh, W., Paling, O., Roosmalen, M.J., van, Tavakoli-Yaraki, M., Victor Guryev, Markus J van Roosmalen   +27 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The E3 Ligase NEDD4L Prevents Colorectal Cancer Liver Metastasis via Degradation of PRMT5 to Inhibit the AKT/mTOR Signaling Pathway

Advanced Science
Colorectal cancer is the second most common cause of cancer mortality worldwide, and liver metastasis is the major cause of death of patients with colorectal cancer.
Zhewen Dong, Xiaofei She, Junxian Ma, Qian Chen, Yaqun Gao, Ruiyan Chen, Huanlong Qin, Bing Shen, Hua Gao   +8 more
doaj   +1 more source

Microbiota in colorectal cancer related to liver metastasis

Chinese Journal of Cancer Research
The prevalence of colorectal cancer (CRC) is increasing annually and metastasis is the principal cause of death in patients with CRC, with the liver being the most frequently affected site. Many studies have shown a strong interplay between the gut flora, particularly Fusobacterium nucleatum (F.
Peijun, Wei, Weiming, Han, Zitong, Zhang, Xue, Tian, Chen, Yang, Qiaoxuan, Wang, Weihao, Xie, Ying, Liu, Yuanhong, Gao, Hui, Chang   +9 more
openaire   +2 more sources

Irreversible electroporation for colorectal cancer liver metastasis: a review

International Journal of Hyperthermia, 2022
Irreversible electroporation (IRE) ablation is gaining popularity over the last decade as a nonthermal alternative to thermal ablation technologies such as radiofrequency ablation (RFA) and Microwave ablation (MWA). This review serves as a practical guide for applying IRE to colorectal cancer liver metastases (CRLM) for interventional radiologists ...
Yilun Koethe, Nicole Wilson, Govindarajan Narayanan   +2 more
openaire   +3 more sources

Taurolidine reduces the tumor stimulating cytokine interleukin-1beta in patients with resectable gastrointestinal cancer : a multicentre prospective randomized trial [PDF]

, 2009
Background The effect of additional treatment strategies with antineoplastic agents on intraperitoneal tumor stimulating interleukin levels are unclear.
Willems Wilhelm, Scheele, Johannes, Gutt, Carsten Nils, Jacobi, Christoph A., Scheele Johannes, Menenakos Charalambos, Müller, Joachim M., Mueller Joachim M, Menenakos, Charalambos, Braumann Chris, Jacobi Christoph A, Willems, Wilhelm, Gutt Carsten N, Braumann, Chris, Christoph A Jacobi, Charalambos Menenakos, Carsten N Gutt, Joachim M Mueller, Wilhelm Willems, Chris Braumann, Johannes Scheele   +20 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source