Results 61 to 70 of about 4,253,992 (294)

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Predictive value of PERK and ATF6 mRNA and protein expression for liver metastasis after laparoscopic radical resection of colorectal cancer

结直肠肛门外科
[Objectives] To investigate the value of PERK and ATF6 mRNA and protein expression in predicting liver metastasis after laparoscopic radical resection of colorectal cancer.
Wang Yi, Zhang Dan, You Xiao
doaj   +1 more source

Clinical characteristics of 39 colorectal cancer patients with liver metastasis.

, 2017
Clinical characteristics of 39 colorectal cancer patients with liver metastasis.
Min Lu (238723), Amelia S. Zessin (3622652), David S. Hsu (272646), Wayne Glover (3622649)   +3 more
core   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Survival Analysis Of Colorectal Cancer Patients With Liver Metastasis [PDF]

, 2020
Background- Colorectal cancer is the third most common cancer in the world. I investigated the survival rates among colorectal cancer patients diagnosed with hepatic metastasis to see if any variables are associated colorectal risk and survival. Methods-
O’Grady, Brandon
core   +1 more source

Guideline for the diagnosis and comprehensive treatment of colorectal cancer liver metastases (2025 edition)

Zhongguo Linchuang Yixue
The liver is the primary target organ for hematogenous metastasis of colorectal cancer, and colorectal cancer liver metastasis is one of the key and challenging aspects in its treatment.
College of Surgeons, Chinese Medical Doctor Association Chinese, Surgery Group, Chinese Society of Surgery, Chinese Medical Association Gastrointestinal, Surgery Group, Chinese Society of Surgery, Chinese Medical Association Colorectal, Cancer Professional Committee, Chinese Anti-Cancer Association Colorectal, Cancer Professional Committee, Chinese Medical Doctor Association Colorectal, Cancer Expert Committee, Chinese Society of Clinical Oncology Colorectal, Surgeons Committee, Chinese Congress of Surgeons, Chinese Medical Doctor Association Colorectal, Metastasis Committee, Anorectal Branch of Chinese Medical Doctor Association Tumor, of Colorectal Oncology, Chinese Society of Oncology, Chinese Medical Association Section, Tumor Therapeutics Branch, China International Exchange and Promotive Association for Medical and Health Care Metastatic, Disease Branch, China International Exchange and Promotive Association for Medical and Health Care Colorectal   +10 more
doaj   +1 more source

Whole exome and transcriptome sequencing reveal clonal evolution and exhibit immune-related features in metastatic colorectal tumors

Cell Death Discovery, 2021
Liver is the most common site where metastatic lesions of colorectal cancer (CRC) arise. Although researches have shown mutations in driver genes, copy number variations (CNV) and alterations in relevant signaling pathways promoted the tumor evolution ...
Chunxue Li, Juan Xu, Xiangfeng Wang, Chao Zhang, Zicheng Yu, Jiucheng Liu, Zaixian Tai, Ziwen Luo, Xin Yi, Zhaoyang Zhong   +9 more
doaj   +1 more source

Clinicopathological Significance of Poorly Differentiated Clusters in Liver Metastatic Lesions of Colorectal Carcinoma

Zhongliu Fangzhi Yanjiu, 2022
Objective To investigate the clinicopathological significance of PDC in liver metastases and analyze the correlation of PDC between liver metastases and primary lesions.
PENG Hui, ZHANG Zhifa, WU Yingjun, ZHANG Xiaohan, ZHU Xianqiang, QIN Haili   +5 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source