Results 61 to 70 of about 141,334 (303)

Loss of PTEN expression is associated with colorectal cancer liver metastasis and poor patient survival

BMC Gastroenterology, 2008
Background The tumour suppressor phosphatase and tensin homolog (PTEN) is an important negative regulator of cell-survival signaling. To evaluate the correlation between PTEN expression and clinicopathological characteristics of colorectal cancer ...
Funahashi Hitoshi, Takahashi Hiroki, Wakasugi Takehiro, Matsuo Yoichi, Ma Jiachi, Ochi Nobuo, Yasuda Akira, Sawai Hirozumi, Sato Mikinori, Takeyama Hiromitsu   +9 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Emerging mechanisms progress of colorectal cancer liver metastasis

Frontiers in Endocrinology, 2022
Colorectal cancer (CRC) is the third most common malignancy and the second most common cause of cancer-related mortality worldwide. A total of 20% of CRC patients present with distant metastasis. The hepatic portal venous system, responsible for collecting most intestinal blood, makes the liver the most common site of CRC metastasis.
Wenhu Zhao, Shipeng Dai, Lei Yue, Fan Xu, Jian Gu, Xinzheng Dai, Xiaofeng Qian   +6 more
openaire   +3 more sources

Total-liver-volume perfusion CT using 3-D image fusion to improve detection and characterization of liver metastases

, 2008
The purpose of this study was to evaluate the feasibility of a totalliver- volume perfusion CT (CTP) technique for the detection and characterization of livermetastases.
Cornelis van Kuijk, van Waesberghe, Jan, Meijer, Sybren, Weide, Lineke van der, Sybren Meijer, van Kuijk, C., van den Tol, Petrousjka, Lineke van der Weide, van den Tol, M.P., van der Weide, L., Meijer, S., van der Weide, Lineke, Meijerink, Martijn, Martijn R. Meijerink, Jan Hein T. M. van Waesberghe, Meijerink, M.R., van Waesberghe, J.H.T.M., Kuijk, Cornelis van, Petrousjka van den Tol, Waesberghe, Jan van, Tol, Petrousjka van den   +20 more
core   +1 more source

Risk factors, prognostic factors, and nomograms for liver metastasis in stage Tis-T2 colorectal cancer patients from a population-based study

Scientific Reports
Liver metastasis(LM) is the primary cause of mortality in patients with colorectal cancer. The incidence of liver metastasis in patients with stage Tis-T2 colorectal cancer is uncommon, and there is limited research available.
Zejin Lin, Zeyu Lin, Taijun Yi, Yongling Liang, Ziyan Mai, Xingyu Li, Chengrui Zhong, Yunle Wan, Guolin Li   +8 more
doaj   +1 more source

N 6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis

Nature Communications, 2019
Liver metastasis of colorectal cancer leads to poor prognosis. Here the authors report that an N 6-methyladenosine modified circular RNA is upregulated in colorectal cancer and promotes liver metastasis by enhancing the stability of HMGA2 mRNA.
Ri-Xin Chen, Xin Chen, Liang-Ping Xia, Jia-Xing Zhang, Zhi-Zhong Pan, Xiao-Dan Ma, Kai Han, Jie-Wei Chen, Jean-Gabrie Judde, Olivier Deas, Feng Wang, Ning-Fang Ma, Xinyuan Guan, Jing-Ping Yun, Feng-Wei Wang, Rui-Hua Xu, Dan Xie   +16 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Surgical treatment of colorectal cancer metastasis

, 2015
Colorectal cancer is one of the most common solid tumors affecting people around the world. A significant proportion of patients with colorectal cancer will develop or will present with liver metastases.
Abdalla, Eddie, Izzo, Francesco, Curley, Steven, Vauthey, Nicolas   +3 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Identificació de nous marcadors moleculars en metàstasi hepàtica de càncer colorectal [PDF]

, 2010
[cat] L’objectiu d’aquest treball és la identificació i caracterització de les principals alteracions en metàstasi hepàtica (MH) de càncer colorectal (CCR) tant a nivell d’expressió gènica com de metilació de l’ADN.
Padullés Mosella, Laura
core