Results 71 to 80 of about 4,253,992 (294)

Macrophage–Fibroblast Crosstalk Governs Tumor Mechanics, as Revealed by Spatiotemporal Force Mapping in 3D Spheroids

Advanced Healthcare Materials, EarlyView.
This study shows crosstalk among tumor cells, fibroblasts, and macrophages alters the physical forces inside 3D tumor spheroids. Incorporating deformable microparticles in 3D tumor spheroids, the researchers mapped mechanical stresses spatially and with respect to tumor growth (temporally).
Kunal P. Pednekar, Daan Vorselen, Jai Prakash   +2 more
wiley   +1 more source

Predictive Value of Albumin-Bilirubin Score Combined with Liver Function Index and CEA for Liver Metastasis of Colorectal Cancer

Xiehe Yixue Zazhi
Objective  To investigate the predictive value of albumin-bilirubin (ALBI) score combined with liver function index and carcinoembryonic antigen (CEA) for liver metastasis of colorectal cancer.
FAN Wanli, HE Dong, ZHANG Shuze, CHEN Gang, ZHAO Bin, CHENG Zhibin   +5 more
doaj   +1 more source

Experimental Colorectal Cancer Liver Metastasis

, 2012
None
Rania B. Georges, Hassan Adwan, Martin R. Berger   +2 more
openaire   +3 more sources

Bioprinted Stiffness‑Tunable Pancreatic Microniches to Decode Early Tumor Initiation Mechanisms

Advanced Healthcare Materials, EarlyView.
Stiffness‐tunable GelMA microniches generated by microvalve bioprinting preserve wild‐type acinar identity while revealing a nonlinear, Kras‐dependent response to matrix mechanics. Intermediate stiffness promotes acinar‐to‐ductal metaplasia and proliferation, defining a permissive mechanical window.
Aurelien Mazet, Charles Handschin, Theo Desigaux, Nathalie Dusserre, Marie‐Laure Stachowicz, Shane Fennell, Malou Lea, Silvia Arcucci, Benoît Thibault, Jean‐Christophe Fricain, Julie Guillermet‐Guibert, Hugo Oliveira   +11 more
wiley   +1 more source

Liver Extracellular Matrix in Colorectal Liver Metastasis

The liver is the most common site of metastasis of colorectal cancer (CRC), and colorectal liver metastasis is one of the major causes of CRC-related deaths worldwide.
Marika Morabito, Anthony Gigandet, Lacotte, Stéphanie, Toso, Christian, Berishvili Berney, Ekaterine, Philippe Compagnon, Stéphanie Lacotte, Morabito, Marika, Thibodot, Pauline, Peloso, Andrea, Pauline Thibodot, Christian Toso, Compagnon, Philippe, Ekaterine Berishvili, Andrea Peloso, Gigandet, Anthony   +15 more
core   +1 more source

“Activation‐Resistance Elimination” Regulation by Lanthanide/Transition Metal Ion‐Coordinated Nanostructures Intensifies Cuproptosis and Tumor Immunotherapy

Advanced Materials, EarlyView.
The lanthanide/transition metal ion coordination nanoparticles, La‐Cu@Lap/IWR‐1, with optimized coordination, have been proven to achieve remarkable results in realizing comprehensive tumor cuproptosis through efficient cuproptosis activation and multidimensional resistance elimination, thereby synchronously realizing the synergistic antitumor effects ...
Junrong Wang, Mengqian Xu, Huaping Zhao, Yulin Xie, Guoqing Zhu, Haoze Li, Qianqian Sun, Yong Lei, Chunxia Li   +8 more
wiley   +1 more source

Chinese guidelines for the diagnosis and comprehensive treatment of colorectal liver metastasis (2025 Edition)

Clinical Cancer Bulletin
The liver is the primary target organ for hematogenous metastasis of colorectal cancer, and colorectal cancer liver metastasis is one of the key and challenging aspects in its treatment.
Jia Fan, Jin Gu, Baoqing Jia, Jin Li, Xinyu Qin, Xishan Wang, Jianmin Xu, Ruihua Xu, Yingjiang Ye, Suzhan Zhang, Zhongtao Zhang, Chinese College of Surgeons, Chinese Medical Doctor Association (CMDA); Gastrointestinal Surgery Group, Chinese Society of Surgery, Chinese Medical Association (CMA); Colorectal Surgery Group, Chinese Society of Surgery, CMA; Colorectal Cancer Professional Committee, Chinese Anti-Cancer Association; Colorectal Cancer Professional Committee, CMDA; Colorectal Cancer Expert Committee, Chinese Society of Clinical Oncology; Colorectal Surgeon Committee, Chinese College of Surgeons, CMDA; Metastasis Research Committee, Chinese Society of Coloproctologu, CMDA; Colorectal Oncology Group, Chinese Society of Oncology, CMA; Metastatic Tumor Therapeutics Branch, China International Exchange and Promotive Association for Medical and Health Care (CPAM); Colorectal Disease Branch, CPAM   +11 more
doaj   +1 more source

Cell‐Based Biohybrid Micro/Nanorobots for Biotherapy

Advanced Robotics Research, EarlyView.
This review systematically evaluates cell‐based biohybrid micro/nanorobots (CB‐BMRs), highlighting their cell selection criteria, fabrication strategies, and diverse actuation modes. Furthermore, it surveys the promising therapeutic applications of CB‐BMRs in targeted cancer, thrombosis, and inflammation treatments, while comprehensively discussing ...
Lin Wang, Chenlu Liu, Yu Zhao, Chuanhua Li, Xuyang Chen, Shixiao Ding, Lizhou Dai, Guokun Wang, Tianlong Li, Jiaxin Li, Xuejia Liu, Haocheng Wang   +11 more
wiley   +1 more source

Does colon cancer ever metastasize to bone first? a temporal analysis of colorectal cancer progression

BMC Cancer, 2009
Background It is well recognized that colorectal cancer does not frequently metastasize to bone. The aim of this retrospective study was to establish whether colorectal cancer ever bypasses other organs and metastasizes directly to bone and whether the ...
Gayed Isis W, Joseph Usha A, Barron Bruce J, Fetzer David T, Roth Eira S, Wan David Q   +5 more
doaj   +1 more source

Phosphorylated STYK1 Promotes Gemcitabine Resistance via Autophagy‐Mediated Cancer Stemness in Pancreatic Cancer

Advanced Science, EarlyView.
Gemcitabine resistance remains a major challenge in pancreatic ductal adenocarcinoma. This study identifies STYK1 as a key mediator of chemoresistance through autophagy‐dependent maintenance of cancer stemness. Gemcitabine‐activated AMPK phosphorylates STYK1 at Ser91 and Ser304, enhancing autophagy and stemness.
Xueying Dong, Shi Li, Chensong Huang, Xuehong Qian, Jieyu Guo, Yahao Guo, Guifang Wu, Qi Zhang, Hongfei Tan, Yu Han, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Chaojun Yan, Wenying Qin, Changchun Li, Xing‐Zhen Chen, Ying Zhao, Cefan Zhou, Jingfeng Tang   +20 more
wiley   +1 more source