Results 71 to 80 of about 141,334 (303)

Suppression of colorectal cancer liver metastasis by apolipoprotein(a) kringle V in a nude mouse model through the induction of apoptosis in tumor-associated endothelial cells.

PLoS ONE, 2014
The formation of liver metastases in colorectal cancer patients is the primary cause of patient death. Current therapies directed at liver metastasis from colorectal cancer have had minimal impact on patient outcomes.
Jin-Hyung Ahn, Hyun-Kyung Yu, Ho-Jeong Lee, Soon Won Hong, Sun Jin Kim, Jang-Seong Kim   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Microbiota in colorectal cancer related to liver metastasis

Chinese Journal of Cancer Research
The prevalence of colorectal cancer (CRC) is increasing annually and metastasis is the principal cause of death in patients with CRC, with the liver being the most frequently affected site. Many studies have shown a strong interplay between the gut flora, particularly Fusobacterium nucleatum (F.
Peijun, Wei, Weiming, Han, Zitong, Zhang, Xue, Tian, Chen, Yang, Qiaoxuan, Wang, Weihao, Xie, Ying, Liu, Yuanhong, Gao, Hui, Chang   +9 more
openaire   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Management of Liver Metastasis of Colorectal Cancer [PDF]

The Egyptian Journal of Hospital Medicine, 2018
Background: Globally, colorectal cancer is the third most common cancer among men and the second most common among women. Colorectal cancer is the fourth most frequently diagnosed cancer, but the second-leading cause of cancer deaths. Incidence of colorectal cancer has decreased significantly in recent decades, mortality rates have fallen as well ...
openaire   +1 more source

Predictive value of PERK and ATF6 mRNA and protein expression for liver metastasis after laparoscopic radical resection of colorectal cancer

结直肠肛门外科
[Objectives] To investigate the value of PERK and ATF6 mRNA and protein expression in predicting liver metastasis after laparoscopic radical resection of colorectal cancer.
Wang Yi, Zhang Dan, You Xiao
doaj   +1 more source

Whole exome and transcriptome sequencing reveal clonal evolution and exhibit immune-related features in metastatic colorectal tumors

Cell Death Discovery, 2021
Liver is the most common site where metastatic lesions of colorectal cancer (CRC) arise. Although researches have shown mutations in driver genes, copy number variations (CNV) and alterations in relevant signaling pathways promoted the tumor evolution ...
Chunxue Li, Juan Xu, Xiangfeng Wang, Chao Zhang, Zicheng Yu, Jiucheng Liu, Zaixian Tai, Ziwen Luo, Xin Yi, Zhaoyang Zhong   +9 more
doaj   +1 more source

Clinicopathological Significance of Poorly Differentiated Clusters in Liver Metastatic Lesions of Colorectal Carcinoma

Zhongliu Fangzhi Yanjiu, 2022
Objective To investigate the clinicopathological significance of PDC in liver metastases and analyze the correlation of PDC between liver metastases and primary lesions.
PENG Hui, ZHANG Zhifa, WU Yingjun, ZHANG Xiaohan, ZHU Xianqiang, QIN Haili   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Long-term Survival after Surgical Resection for Liver Metastasis from Gastric Cancer: Two Case Reports [PDF]

, 2006
Surgical resection of colorectal cancer metastasis to the liver results in a 5-year survival rate of around 40%. Liver metastasis from other cancers such as neuroendocrine carcinoma and genitourinary tumors are also treated effectively with combined ...
정희철, 라선영, 정현철, 노재경, 안중배, 김호근, 노성훈   +6 more
core   +1 more source