Results 91 to 100 of about 141,334 (303)
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
, 2023 Background: To determine the long-term outcomes of radiofrequency ablation with respect to overall survival, disease-free survival, and complications in patients with colorectal cancer liver metastases.
Okan Akhan +11 more
core +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
Experimental Colorectal Cancer Liver Metastasis
, 2012 With estimated 1 080 000 diagnosed cases each year, which account for 1.1% of all deaths, colorectal carcinoma (CRC) ranks fourth in cancer-related deaths in both sexes worldwide (WHOSIS, 2008). In Europe, CRC is the third most lethal malignancy after lung and stomach cancers in men, and it ranks second after breast cancer in women (WHOSIS, 2008).
Rania B., Hassan Adwan, Martin R.
openaire +2 more sources
Investigation of the roles of exosomes in colorectal cancer liver metastasis
Oncology Reports, 2015 The leading cause of death among cancer patients is tumor metastasis. Tumor-derived exosomes are emerging as mediators of metastasis. In the present study, we demonstrated that exosomes play a pivotal role in the metastatic progression of colorectal cancer.
Xia, Wang +11 more
openaire +3 more sources
Liver Extracellular Matrix in Colorectal Liver Metastasis
The liver is the most common site of metastasis of colorectal cancer (CRC), and colorectal liver metastasis is one of the major causes of CRC-related deaths worldwide.
Marika Morabito +15 more
core +1 more source
Irreversible Electroporation for Liver Metastases from Colorectal Cancer: A Systematic Review
, 2023 Background: Irreversible electroporation (IRE) is a non-thermal form of ablation based on the delivery of pulsed electrical fields. It has been used to treat liver lesions, particularly those in proximity to major hepatic vasculature.
Vinotha Nadarajah +7 more
core +1 more source
World Journal of Surgical Oncology, 2022 Objective This paper aims to explore the diagnostic value of enhanced magnetic resonance imaging (MRI) combined with a carcinoembryonic antigen (CEA) and carbohydrate antigen in terms of the liver metastasis of colorectal cancer.
Hua-qiang Zhu +5 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.We describe a microfluidic tumor‐stroma co‐culture model, engineered to resist collagen‐hydrogel contraction driven by fibroblast activity. Surface silanization with APTES covalently anchors the matrix to the chip, while Genipin crosslinking progressively increases stiffness and elasticity without harming cells. This supports >10 days of co‐culture and
Doriane Le Manach +4 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Sweetosomes, a new class of fucose‐decorated liposomes, are developed via a one‐step microfluidic process without surface chemistry. This study elucidates their main caveolae‐mediated entry and distinct endosomal trafficking. These nanostructures demonstrate superior endosomal escape, organelle acidity modulation, and prolonged plasma persistence ...
Mattia Tiboni +13 more
wiley +1 more source