Results 81 to 90 of about 141,334 (303)

Guideline for the diagnosis and comprehensive treatment of colorectal cancer liver metastases (2025 edition)

Zhongguo Linchuang Yixue
The liver is the primary target organ for hematogenous metastasis of colorectal cancer, and colorectal cancer liver metastasis is one of the key and challenging aspects in its treatment.
College of Surgeons, Chinese Medical Doctor Association Chinese, Surgery Group, Chinese Society of Surgery, Chinese Medical Association Gastrointestinal, Surgery Group, Chinese Society of Surgery, Chinese Medical Association Colorectal, Cancer Professional Committee, Chinese Anti-Cancer Association Colorectal, Cancer Professional Committee, Chinese Medical Doctor Association Colorectal, Cancer Expert Committee, Chinese Society of Clinical Oncology Colorectal, Surgeons Committee, Chinese Congress of Surgeons, Chinese Medical Doctor Association Colorectal, Metastasis Committee, Anorectal Branch of Chinese Medical Doctor Association Tumor, of Colorectal Oncology, Chinese Society of Oncology, Chinese Medical Association Section, Tumor Therapeutics Branch, China International Exchange and Promotive Association for Medical and Health Care Metastatic, Disease Branch, China International Exchange and Promotive Association for Medical and Health Care Colorectal   +10 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Construction of a prognostic model for colorectal cancer liver metastasis based on single-cell transcriptomics and regulation of the MIF pathway. [PDF]

Front Oncol
IntroductionColorectal cancer is associated with a generally poor prognosis, primarily due to its often late diagnosis and the high propensity for liver metastasis.
Cao J, He Z, Gao H, Yu Y, Yang S, Wang X, Niu J, Peng C.   +7 more
europepmc   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Metastasectomy of Combined Liver and Lung Colorectal Cancer Metastases

, 2015
The liver is the exclusive site of metastasis in approximately 30% to 50% of patients with stage IV colorectal cancer, whereas lung metastasis occurs in 10% to 20% of patients.
Abdalla, Eddie, Contreras, Carlo
core   +1 more source

Suppression of Colorectal Cancer Liver Metastasis and Extension of Survival by Expression of Apolipoprotein(a) Kringles [PDF]

, 2004
The formation of hepatic metastases in colorectal cancer is the main cause of patient death. Current therapies directed at hepatic metastasis of colorectal cancer have had minimal impact on outcome.
홍순원
core   +1 more source

Predictive Value of Albumin-Bilirubin Score Combined with Liver Function Index and CEA for Liver Metastasis of Colorectal Cancer

Xiehe Yixue Zazhi
Objective  To investigate the predictive value of albumin-bilirubin (ALBI) score combined with liver function index and carcinoembryonic antigen (CEA) for liver metastasis of colorectal cancer.
FAN Wanli, HE Dong, ZHANG Shuze, CHEN Gang, ZHAO Bin, CHENG Zhibin   +5 more
doaj   +1 more source

Does colon cancer ever metastasize to bone first? a temporal analysis of colorectal cancer progression

BMC Cancer, 2009
Background It is well recognized that colorectal cancer does not frequently metastasize to bone. The aim of this retrospective study was to establish whether colorectal cancer ever bypasses other organs and metastasizes directly to bone and whether the ...
Gayed Isis W, Joseph Usha A, Barron Bruce J, Fetzer David T, Roth Eira S, Wan David Q   +5 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Chinese guidelines for the diagnosis and comprehensive treatment of colorectal liver metastasis (2025 Edition)

Clinical Cancer Bulletin
The liver is the primary target organ for hematogenous metastasis of colorectal cancer, and colorectal cancer liver metastasis is one of the key and challenging aspects in its treatment.
Jia Fan, Jin Gu, Baoqing Jia, Jin Li, Xinyu Qin, Xishan Wang, Jianmin Xu, Ruihua Xu, Yingjiang Ye, Suzhan Zhang, Zhongtao Zhang, Chinese College of Surgeons, Chinese Medical Doctor Association (CMDA); Gastrointestinal Surgery Group, Chinese Society of Surgery, Chinese Medical Association (CMA); Colorectal Surgery Group, Chinese Society of Surgery, CMA; Colorectal Cancer Professional Committee, Chinese Anti-Cancer Association; Colorectal Cancer Professional Committee, CMDA; Colorectal Cancer Expert Committee, Chinese Society of Clinical Oncology; Colorectal Surgeon Committee, Chinese College of Surgeons, CMDA; Metastasis Research Committee, Chinese Society of Coloproctologu, CMDA; Colorectal Oncology Group, Chinese Society of Oncology, CMA; Metastatic Tumor Therapeutics Branch, China International Exchange and Promotive Association for Medical and Health Care (CPAM); Colorectal Disease Branch, CPAM   +11 more
doaj   +1 more source