Results 51 to 60 of about 4,253,992 (294)

Loss of PTEN expression is associated with colorectal cancer liver metastasis and poor patient survival

BMC Gastroenterology, 2008
Background The tumour suppressor phosphatase and tensin homolog (PTEN) is an important negative regulator of cell-survival signaling. To evaluate the correlation between PTEN expression and clinicopathological characteristics of colorectal cancer ...
Funahashi Hitoshi, Takahashi Hiroki, Wakasugi Takehiro, Matsuo Yoichi, Ma Jiachi, Ochi Nobuo, Yasuda Akira, Sawai Hirozumi, Sato Mikinori, Takeyama Hiromitsu   +9 more
doaj   +1 more source

Risk factors, prognostic factors, and nomograms for liver metastasis in stage Tis-T2 colorectal cancer patients from a population-based study

Scientific Reports
Liver metastasis(LM) is the primary cause of mortality in patients with colorectal cancer. The incidence of liver metastasis in patients with stage Tis-T2 colorectal cancer is uncommon, and there is limited research available.
Zejin Lin, Zeyu Lin, Taijun Yi, Yongling Liang, Ziyan Mai, Xingyu Li, Chengrui Zhong, Yunle Wan, Guolin Li   +8 more
doaj   +1 more source

N 6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis

Nature Communications, 2019
Liver metastasis of colorectal cancer leads to poor prognosis. Here the authors report that an N 6-methyladenosine modified circular RNA is upregulated in colorectal cancer and promotes liver metastasis by enhancing the stability of HMGA2 mRNA.
Ri-Xin Chen, Xin Chen, Liang-Ping Xia, Jia-Xing Zhang, Zhi-Zhong Pan, Xiao-Dan Ma, Kai Han, Jie-Wei Chen, Jean-Gabrie Judde, Olivier Deas, Feng Wang, Ning-Fang Ma, Xinyuan Guan, Jing-Ping Yun, Feng-Wei Wang, Rui-Hua Xu, Dan Xie   +16 more
doaj   +1 more source

Management of Liver Metastasis of Colorectal Cancer [PDF]

The Egyptian Journal of Hospital Medicine, 2018
Background: Globally, colorectal cancer is the third most common cancer among men and the second most common among women. Colorectal cancer is the fourth most frequently diagnosed cancer, but the second-leading cause of cancer deaths. Incidence of colorectal cancer has decreased significantly in recent decades, mortality rates have fallen as well ...
openaire   +1 more source

Population screening for colorectal cancer means getting FIT:the past, present, and future of colorectal cancer screening using the fecal immunochemical test for hemoglobin (FIT) [PDF]

, 2014
Fecal immunochemical tests for hemoglobin (FIT) are changing the manner in which colorectal cancer (CRC) is screened. Although these tests are being performed worldwide, why is this test different from its predecessors?
Halloran, SP, Fraser, Callum G., Fraser, CG, Young, Graeme P., Halloran, Stephen P., Allison, JE, Allison, James E., Young, GP   +7 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Suppression of colorectal cancer liver metastasis by apolipoprotein(a) kringle V in a nude mouse model through the induction of apoptosis in tumor-associated endothelial cells.

PLoS ONE, 2014
The formation of liver metastases in colorectal cancer patients is the primary cause of patient death. Current therapies directed at liver metastasis from colorectal cancer have had minimal impact on patient outcomes.
Jin-Hyung Ahn, Hyun-Kyung Yu, Ho-Jeong Lee, Soon Won Hong, Sun Jin Kim, Jang-Seong Kim   +5 more
doaj   +1 more source

Can localised 19F magnetic resonance spectroscopy pharmacokinetics of 5FU in colorectal metastases predict clinical response? [PDF]

, 2010
Background 5-Fluorouracil remains widely used in colorectal cancer treatment more than 40 years after its development. 19F magnetic resonance spectroscopy can be used in vivo to measure 5FU’s half-life and metabolism to cytotoxic fluoronucleotides ...
Griffiths, John R., Ladroue, Christophe, Lofts, F, Lofts, Fiona, Griffiths, JR, John R. Griffiths, Marion Stubbs, Stubbs, Marion, Franklyn A. Howe, Fiona Lofts, McIntyre, DJ, Ladroue, C, Howe, FA, Howe, Franklyn A., McIntyre, Dominick J. O., Dominick J. O. McIntyre, Stubbs, M, Christophe Ladroue   +17 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

TYK2 Promotes Immunosurveillance of Colorectal Cancer Liver Metastasis. [PDF]

Cancer Res
Abstract Colorectal cancer liver metastasis (CRLM) is a major clinical problem. The regulators of immunosurveillance of CRLM could hold potential for developing therapeutic strategies to prevent or treat metastasis. In this study, using a murine colorectal cancer organoid-based transplantation
Mödl B, Zwolanek D, Schwertner K, Krauß D, Moritsch S, Scharf I, Ebner AS, Moreno-Viedma V, de Sa Fernandes C, Novoszel P, Holcmann M, Hammer M, Matrone N, Schlederer M, Strobl B, Casanova E, Lassnig C, Herndler-Brandstetter D, Kenner L, Müller M, Sibilia M, Eferl R.   +21 more
europepmc   +3 more sources