Results 11 to 20 of about 141,334 (303)

Radiomics and Radiogenomics in Evaluation of Colorectal Cancer Liver Metastasis [PDF]

Frontiers in Oncology, 2022
Colorectal cancer is one common digestive malignancy, and the most common approach of blood metastasis of colorectal cancer is through the portal vein system to the liver. Early detection and treatment of liver metastasis is the key to improving the prognosis of the patients.
Xiao-Ping Yin, Bu-Lang Gao, Wang Yun
exaly   +5 more sources

Multilevel Heterogeneity of Colorectal Cancer Liver Metastasis

Cancers, 2023
Colorectal cancer liver metastasis (CRLM) is a highly heterogeneous disease. Therapies that target both primary foci and liver metastasis are severely lacking. Therefore, understanding the features of metastatic tumor cells in the liver is valuable for the overall control of CRLM patients.
Hao Chen, Chongya Zhai, Xian Xu, Haidong Wang, Weidong Han, Jiaying Shen   +5 more
openaire   +3 more sources

A multidimensional integration analysis reveals potential bridging targets in the process of colorectal cancer liver metastasis [PDF]

PLoS ONE, 2017
Approximately 9% of cancer-related deaths are caused by colorectal cancer. Liver metastasisis a major factor for the high colorectal cancer mortality rate.
Dongbo Xue, Qin Shao, Gao, Bo, Gao, Zu-hua, Bo Gao, Yuguo Zhang, Zhang, Weihui, Zu-Hua Gao, Xue, Dongbo, Marcus, Victoria, Boshi Sun, Yu, Tian, Shao, Qin, Weihui Zhang, Victoria Marcus, Jiannis Ragoussis, Ragoussis, Jiannis, Tian Yu, Sun, Boshi, Choudhry, Hani, Zhang, Yuguo, Hani Choudhry   +21 more
core   +2 more sources

Liver Immune Microenvironment and Metastasis from Colorectal Cancer-Pathogenesis and Therapeutic Perspectives [PDF]

Cancers, 2021
A drastic difference exists between the 5-year survival rates of colorectal cancer patients with localized cancer and distal organ metastasis. The liver is the most favorable organ for cancer metastases from the colorectum.
Xuezhen Zeng, Simon E Ward, Jingying Zhou   +2 more
exaly   +2 more sources

Whole genome analysis for liver metastasis gene signatures in colorectal cancer

International Journal of Cancer, 2007
Liver metastasis is one of the major causes of death in colorectal cancer (CRC) patients. To understand this process, we investigated whether the gene expression profiling of matched colorectal carcinomas and liver metastases could reveal key molecular ...
Hei-Cheul Jeung, Chan Hee Park
exaly   +2 more sources

Perioperative Chemotherapy for Liver Metastasis of Colorectal Cancer [PDF]

Cancers, 2020
The liver is the dominant site of metastasis for patients with colorectal cancer. For those with isolated liver metastases, surgical resection with systemic therapy has led to long-term remission in as high as 80% of patients in well-selected cohorts. This review will focus on how systemic therapy should be integrated with resection of liver metastases;
Gloria Chan, Cheng E. Chee
openaire   +2 more sources

The role of the immunoescape in colorectal cancer liver metastasis

PLOS ONE, 2021
The expression of programmed death 1 (PD-1) and programmed death-ligand 1 (PD-L1) indicate the efficacy of anti-PD-1/PD-L1 therapy in colorectal cancer (CRC), but are less useful for monitoring the efficacy of therapy of CRC liver metastasis (CRLM). This study investigated the effects of immune molecules on the prognosis of CRLM.
Chie Takasu, Shoko Yamashita, Yuji Morine, Kozo Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Toshiaki Yoshimoto, Mitsuo Shimada   +8 more
openaire   +5 more sources

microRNA biomarkers in colorectal cancer liver metastasis [PDF]

Journal of Cancer, 2018
Liver metastasis is a primary factor of prognosis and long-term survival for patients diagnosed with colorectal cancer (CRC). Colorectal cancer liver metastasis (CRCLM), is a complex biological process involving multiple factors and steps, and its mechanisms are yet to be discovered.
Huang, Shulin, Tan, Xiaohui, Huang, Zhongcheng, Chen, Zihua, Lin, Paul, Fu, Sidney W.   +5 more
openaire   +2 more sources

CircNOLC1 Promotes Colorectal Cancer Liver Metastasis by Interacting with AZGP1 and Sponging miR‐212‐5p to Regulate Reprogramming of the Oxidative Pentose Phosphate Pathway

Advanced Science, 2023
Liver metastasis is a common cause of death in progressive colorectal cancer patients, but the molecular mechanisms remain unclear. Here, it is reported that a conserved and oxidative pentose phosphate pathway‐associated circular RNA, circNOLC1, plays a ...
Menglang Yuan, Xinsheng Zhang, Fangxia Yue, Feifan Zhang, Sufen Jiang, Xu Zhou, Jinjuan Lv, Zhenyu Zhang, Yuzhu Sun, Zihao Chen, Han Wu, Xiaoqian Liu, Xiaoqi Yu, Bowen Wei, Kexin Jiang, Fang Lin, Yunfei Zuo, Shuangyi Ren   +17 more
doaj   +1 more source

Effect of Chronic Psychological Stress on Liver Metastasis of Colon Cancer in Mice. [PDF]

PLoS ONE, 2015
Metastasis to the liver is a main factor in colorectal cancer mortality. Previous studies suggest that chronic psychological stress is important in cancer progression, but its effect on liver metastasis has not been investigated.
Lu Zhao, Jianhua Xu, Fang Liang, Ao Li, Yong Zhang, Jue Sun   +5 more
doaj   +1 more source