Results 91 to 100 of about 855,584 (391)

Effects of supplemental vitamin D and calcium on markers of proliferation, differentiation, and apoptosis in the normal colorectal mucosa of colorectal adenoma patients.

PLoS ONE, 2018
To clarify the roles of vitamin D and calcium as potential chemopreventive agents against colorectal cancer in humans, and to develop "treatable", pre-neoplastic, phenotypic biomarkers of risk for colorectal neoplasms, we estimated the effects of ...
Yasheen Gao, Caroline Y Um, Veronika Fedirko, Robin E Rutherford, March E Seabrook, Elizabeth L Barry, John A Baron, Roberd M Bostick   +7 more
doaj   +1 more source

Novel Method for Screening Colorectal Neoplasm

EBioMedicine, 2015
Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide with the majority of cases having no previous family history. The most effective way to reduce mortality is to detect precancerous adenoma in an early stage. Several screening methods are now available; however as each modality has its limitation there is no superb strategy ...
openaire   +4 more sources

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

The paradox of cancer genes in non-malignant conditions: implications for precision medicine. [PDF]

, 2020
Next-generation sequencing has enabled patient selection for targeted drugs, some of which have shown remarkable efficacy in cancers that have the cognate molecular signatures.
Adashek, Jacob J, Kato, Shumei, Kurzrock, Razelle, Lippman, Scott M   +3 more
core  

A Novel Opportunity in Minimally Invasive Colorectal Cancer Therapy: Defining a Role for Endoscopic Submucosal Dissection in the United States [PDF]

, 2013
Colorectal cancer is the third most common cancer among both men and women in the United States and the second leading cause of cancer death.
Cohen, Jonah
core   +2 more sources

Clinicopathological hallmarks and biomarkers of colorectal neuroendocrine neoplasms

PLOS ONE, 2017
Chromogranin A (CgA) is a well-established marker for diagnosis and follow up of patients with gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN). Recently, it has been shown that plasma levels of CgA correlate with tumor load and predict survival of patients with NEN of the small bowel.
Sebastian Krug, Sebastian Krug, Patrick Michl, Philipp Stroebel, Peter H. Kann, Michael Scharf, Volker Ellenrieder, Alexander Koenig, Alexander Koenig, Thomas M. Gress, Peter Barth, Peter Barth, Anja Rinke, Daniela Mueller, Kia Homayunfar, Roland Moll, Ute Koenig   +16 more
openaire   +6 more sources

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source

Efficacy of capillary pattern type IIIA/IIIB by magnifying narrow band imaging for estimating depth of invasion of early colorectal neoplasms

BMC Gastroenterology, 2010
Background Capillary patterns (CP) observed by magnifying Narrow Band Imaging (NBI) are useful for differentiating non-adenomatous from adenomatous colorectal polyps.
Fu Kuang-I, Uraoka Toshio, Saito Yutaka, Emura Fabian, Matsuda Takahisa, Ikematsu Hiroaki, Kaneko Kazuhiro, Ochiai Atsushi, Fujimori Takahiro, Sano Yasushi   +9 more
doaj   +1 more source

Colorectal Neuroendocrine Neoplasms: Areas of Unmet Need [PDF]

Neuroendocrinology, 2018
The subject of colorectal neuroendocrine neoplasms (NENs), subdivided into well-differentiated NENs, termed neuroendocrine tumours (NETs; grade (G) 1 and 2), and poorly differentiated NENs, termed neuroendocrine carcinomas (NECs; G3) according to the 2010 World Health Organisation (WHO) classification, has arguably not had as much attention or study as
Ramage, JK, Valle, JW, Nieveen, Van Dijkum EJM, Sundin, A, Pascher, A, Couvelard, A, Kloeppel, G, on behalf of The ENETS 2016 MunichAdvisory Board Partecipants, Partelli, S, Falconi, M   +9 more
openaire   +3 more sources

Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance

Molecular Oncology, EarlyView.
In this research, we analyzed the relationship between gut microbiota and tumor. We discovered that both subcutaneous and metastatic tumors would alter the composition and metabolic function of gut microbiota. Meanwhile, fecal microbiota transplantation also indicated the anti‐tumor role of the gut microbiota, revealing the crosstalk between tumor and ...
Siyuan Zhang, Haimei Wen, Ying Chen, Jingya Ning, Di Hu, Yujiao Dong, Chenyu Yao, Bo Yuan, Shuanying Yang   +8 more
wiley   +1 more source