Results 71 to 80 of about 353,689 (293)

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Clinical trial protocol of the ASTER trial: a double-blind, randomized, placebo-controlled phase III trial evaluating the use of acetylsalicylic acid (ASA) for enhanced early detection of colorectal neoplasms

BMC Cancer, 2018
ᅟ Immunochemical fecal occult blood tests (iFOBTs) are increasingly used for colorectal cancer (CRC) screening. In our preceding observational study, sensitivity for detecting advanced colorectal neoplasms by iFOBT was 70.8% among users of low-dose ...
Kaja Tikk, David Czock, Walter E. Haefeli, Annette Kopp-Schneider, Hermann Brenner   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Presence of Iron in Colorectal Adenomas and Adenocarcinomas

Gut and Liver, 2008
Background/Aims: Iron overload reportedly increases the risk of colorectal neoplasms, but the distribution of tissue iron in a colorectal neoplasm remains controversial.
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Screen for Life: National Colorectal Cancer Action Campaign 2017 year end report [PDF]

CDC\u2019s Screen for Life: National Colorectal Cancer Action Campaign is a multiyear, multimedia campaign to raise awareness of the life-saving benefits of colorectal cancer screening for men and women aged 50\u201375.

core  

ENETS Consensus Guidelines for the management of patients with digestive neuroendocrine neoplasms: colorectal neuroendocrine neoplasms. [PDF]

, 2012
ENETS Consensus Guidelines for the management of patients with digestive neuroendocrine neoplasms: colorectal neuroendocrine ...
O'Connor J, Baum R, Cadiot G, K. J. Klose, Grossman A, Sauvanet A, Scoazec JY, Bartsch D, Delle Fave G, Costa F, Pascher A, Brandi ML, Salazar R, Kianmanesh R, Plöckinger U, Klose KJ, Knigge U, Baudin E, Sundin A, Kelestimur F, FALCONI , MASSIMO, O. Nillson, M. Papotti, R. Salazar, Denecke T, Klöppel G, M. Caplin, Perren A, Eriksson B, F. Kelestimur, de Herder W, A. Sundin, Kwekkeboom D, Krenning E, Komminoth P, Ruszniewski P, Pavel M, Taal B, Vullierme MP, Nilsson O, Niederle B, Kos Kudla B, Arnold R, Rindi G, Tomassetti P, FALCONI, Massimo, Couvelard A, A. Pascher, Van Cutsem E, Öberg K, Jensen R, Sasano H, Caplin M, B. C. Conference Anlauf M, Wiedenmann B., U. Plöckinger, Gress T, Lopes JM, O'Toole D, Steinmüller T, Papotti M, Kaltsas G, Pape UF, Gross D, R. P. Baum   +64 more
core   +1 more source

Efficacy of capillary pattern type IIIA/IIIB by magnifying narrow band imaging for estimating depth of invasion of early colorectal neoplasms

BMC Gastroenterology, 2010
Background Capillary patterns (CP) observed by magnifying Narrow Band Imaging (NBI) are useful for differentiating non-adenomatous from adenomatous colorectal polyps.
Fu Kuang-I, Uraoka Toshio, Saito Yutaka, Emura Fabian, Matsuda Takahisa, Ikematsu Hiroaki, Kaneko Kazuhiro, Ochiai Atsushi, Fujimori Takahiro, Sano Yasushi   +9 more
doaj   +1 more source