Results 181 to 190 of about 353,689 (293)

Topology‐Aware Deep Learning on Higher‐Order Structures for Drug Response Prediction

Advanced Science, EarlyView.
We present TopDr, a topology‐aware deep learning framework that encodes both drugs and cell lines as multiscale simplicial complexes, capturing interactions at the 0‐, 1‐, and 2‐simplex levels. By jointly integrating local higher‐order neighborhoods and global topological structures, TopDr generates enriched representations for sensitivity prediction ...
Cong Shen, Guancen Lin, Chuan‐Shen Hu, Yong Wang   +3 more
wiley   +1 more source

Screening helps prevent colorectal cancer [PDF]

Of cancers that affect both men and women, colorectal (colon) cancer is the second leading cancer killer in the United States. But this is one cancer you can prevent!

core  

Association Between Longer Cecal Intubation Time and Detection and Miss Rate of Colorectal Neoplasms. [PDF]

J Clin Med
Choi JM, Lim SH, Han YM, Lee J, Jin EH, Seo JY, Kim J.   +6 more
europepmc   +1 more source

Effectiveness of Inner Traction-Facilitated Endoscopic Submucosal Dissection Using Rubber Band and Clips for Colorectal Neoplasms: A Propensity Score-Matched Study. [PDF]

Turk J Gastroenterol, 2023
Liu G, Guo X, Cai Y, Rong L, Nian W, Zhang J.   +5 more
europepmc   +1 more source

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

Development and validation of computer-aided detection for colorectal neoplasms using deep learning incorporated with computed tomography colonography. [PDF]

BMC Gastroenterol
Endo S, Nagata K, Utano K, Nozu S, Yasuda T, Takabayashi K, Hirayama M, Togashi K, Ohira H.   +8 more
europepmc   +1 more source

Application of intralesional traction assistance with traction wire to endoscopic submucosal dissection for colorectal neoplasms. [PDF]

Endoscopy, 2022
Nasu T, Esaki M, Shoguchi Y, Bai X, Minoda Y, Ogino H, Ihara E.   +6 more
europepmc   +1 more source

Targeting KDM3B Elicits Anti‐tumor Immunity by Alleviating SHP1–mediated STING Suppression in Triple–Negative Breast Cancer

Advanced Science, EarlyView.
P3FI–90 treatment targets KDM3B, reshapes the epigenetic landscape, and suppresses SHP1 expression, thereby activating STING–TBK1–IRF3–type I IFN signaling pathway. Consequently, CD8+ T cells are recruited to the tumor site and activated to produce IFN–γ and GZMB, leading to the killing of TNBC cells.
Xiaolong Wang, Wenhao Li, Yifei Wang, Ning Zhang, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Qifeng Yang   +8 more
wiley   +1 more source

Use of Laxative-Augmented Contrast Medium Increases the Accuracy in the Detection of Colorectal Neoplasms. [PDF]

Diagnostics (Basel)
Chen LY, Chen JD, Chen YK.
europepmc   +1 more source

Association of sleep duration, sleep apnea, and shift work with risk of colorectal neoplasms: a systematic review and meta-analysis. [PDF]

J Gastrointest Oncol, 2022
Wang G, Wang JJ, Lin CH, Zhou Q, Wang WL, Qin T, Li X, Wang ZJ.   +7 more
europepmc   +1 more source