Results 161 to 170 of about 353,689 (293)

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

Pharmacodynamics of direct oral anticoagulants associated with post-endoscopic delayed mucosal resection bleeding of colorectal neoplasms. [PDF]

Sci Rep
Murata M, Sugimoto M, Ueshima S, Nagami Y, Ominami M, Furumoto Y, Mikami T, Sawaya M, Yoshida N, Inoue K, Maruyama Y, Terai T, Tsuji S, Yamamura T, Yamada T, Takeuchi Y, Yagi N, Osawa S, Yoshizawa Y, Orihara S, Miyamoto S, Matsuda S, Hira D, Terada T, Katsura T, Fujishiro M, Kawai T.   +26 more
europepmc   +1 more source

Triglyceride glucose index and Atherogenic index of plasma for predicting colorectal neoplasms in patients without cardiovascular diseases. [PDF]

Front Oncol, 2022
Han M, Wang H, Yang S, Zhu S, Zhao G, Shi H, Li P.   +6 more
europepmc   +1 more source

From Label‐Free Multiphoton Imaging to Pathological Reports: A Vision‐Language Breast Cancer Margin Pathological Diagnosis System

Advanced Science, EarlyView.
MarginPath is a novel vision‐language system that automates breast cancer margin assessment using a single label‐free multiphoton microscopy image. By integrating tumor‐associated collagen signatures with virtual H&E imaging, it generates accurate margin heatmaps and comprehensive diagnostic reports.
Shu Wang, Jingze Su, Xiahui Han, Deyong Kang, Xiao Zhang, Fei Xu, Changzu Liu, Junlin Pan, Xingfu Wang, Qiaohui Zhan, Aimin Wang, Feng Huang, Heping Cheng, Wenxi Liu, Ruolan Lin, Jianxin Chen   +15 more
wiley   +1 more source

Safety Profile of Low-Power Pure-Cut Hot Snare Polypectomy for 10-14 mm Nonpedunculated Colorectal Neoplasms. [PDF]

DEN Open
Takada K, Kimura H, Hotta K, Imai K, Ito S, Kishida Y, Kawata N, Yoshida M, Yamamoto Y, Minamide T, Ishiwatari H, Sato J, Matsubayashi H, Ono H.   +13 more
europepmc   +1 more source

Robotic natural orifice specimen extraction surgery versus conventional robotic resection for patients with colorectal neoplasms. [PDF]

Front Oncol, 2023
Li L, Liu K, Li T, Zhou J, Xu S, Yu N, Guo Z, Yao H.   +7 more
europepmc   +1 more source

Compact Tabletop Magnetic Resonance Elastography for Mapping Soft Tissue Viscoelasticity

Advanced Science, EarlyView.
This work introduces a compact, low‐cost tabletop magnetic resonance elastography platform for high‐resolution viscoelastic mapping in soft‐tissue specimens. Using this method in human colorectal liver metastases, we demonstrate fully automated biomechanical profiling of treatment response and show that heterogeneity‐based metrics outperform ...
Weijie Zhao, Lisa‐Marie Skrip, Heiko Tzschätzsch, Tom Meyer, Hossein S. Aghamiry, Alexander Arnold, Lene Änne Böhne, Jakob Jordan, Oliver Boehm, Agnes K. Boehm, Steffen Görner, Jakob Schattenfroh, Yanglei Wu, Pedro Augusto Dantas de Moraes, Johann Pratschke, Jürgen Braun, Igor M. Sauer, Jing Guo, Ingolf Sack, Karl H. Hillebrandt   +19 more
wiley   +1 more source

Analysis of the correlation between non-alcoholic fatty liver disease and the risk of colorectal neoplasms. [PDF]

Front Pharmacol, 2022
Ye S, Liu Y, Zhang T, Feng H, Liu Y, Ma L.   +5 more
europepmc   +1 more source

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

Gel-immersion Endoscopic Submucosal Dissection for Superficial Colorectal Neoplasms: A Retrospective Study Comparing Conventional Endoscopic Submucosal Dissection. [PDF]

DEN Open
Yamauchi K, Inaba T, Morimoto T, Colvin HS, Nakanishi A, Ishikawa S, Wato M.   +6 more
europepmc   +1 more source