Results 241 to 250 of about 699,211 (296)

ROS/pH‐Responsive Phenylboronic Acid–Chitosan Nanoparticles Improve Silymarin‐Mediated Hepatoprotection After Hepatectomy With Gut‐Liver Axis‐Associated Responses

Advanced Science, EarlyView.
Bioactive phenylboronic acid–chitosan nanoparticles enable responsive silymarin delivery for post‐hepatectomy liver protection. The nanoplatform integrates antioxidant and antibacterial functions, improves hepatic recovery, and is associated with coordinated shifts in gut microbiota, metabolites, cytokines, and hepatic proteomic pathways, suggesting a ...
Jinjin Tong, Chaochao Luo, Zezheng Liu, Xinyan Zhang, Daixu Jia, Yang Sun, Zhaonan Zhang, Haoran Shi, Jianfang Wang, Hua Zhang   +9 more
wiley   +1 more source

Asymmetric Structure‐Driven Functional Synergy: A Multistimuli‐Activated Janus Nanomotor for Self‐Amplifying NO Cascade Therapy

Advanced Science, EarlyView.
The Janus nanomotors leverage an “asymmetric structure‐driven functional synergy” strategy to orchestrate spatiotemporally coordinated catalytic functions, in situ self‐amplifying NO generation, and deep tumor penetration, thereby enabling controllable, sustained, and uniform NO generation within the tumor microenvironment.
Chengcheng Li, Yu Zhang, Yu Chen, Lingyun He, Xian Shen, Weijian Sun, Hongbo Zhang   +6 more
wiley   +1 more source

DeepLNM: A Multimodal Model for Predicting Lymph Node Metastasis in Colorectal Cancer

Advanced Science, EarlyView.
Traditional diagnosis may miss positive LNM cases, and pathologists face a workload; therefore, we develop DeepLNM, a multimodal model that predicts lymph node metastasis in colorectal cancer from H&E WSIs, CT images, and text. DeepLNM is robust across internal, external, and prospective cohorts and, in a user study, improves diagnostic accuracy while ...
Zhengyu Zhang, Chengyu Lu, Zhen Wang, Zhijian Cen, Yangshu Zhou, Danyi Li, Qi Xie, Bingbing Li, Shujing Guo, Zhijun Gan, Er‐ran Zhu, Jinbang Li, Aihetaimu Aimaier, Rui Mao, Weihao Qiu, Chenglong Zhao, Ying Tan, Xiaolin Liu, Huiting Ma, Tiansu Geng, Peiyue Wu, Huijun Du, Yu Wang, Yueping Liu, Li Liang   +24 more
wiley   +1 more source

Risk Factors for Post-Endoscopic Submucosal Dissection Electrocoagulation Syndrome in Patients with Colorectal Neoplasms: A Multicenter, Large-Scale, Retrospective Cohort Study by the Honam Association for the Study of Intestinal Disease (HASID). [PDF]

J Clin Med
Song HY, Kim SJ, Lee J, Jin BC, Kim DH, Kim HS, Oh HH, Joo YE, Myung DS, Kim SW, Seo GS.   +10 more
europepmc   +1 more source

TROP2‐Targeting Chimeras (TRTACs) for Tumor Cell‐Selective Membrane Protein Degradation and Enhanced Drug Delivery

Advanced Science, EarlyView.
TROP2 is identified as a novel tumor‐selective lysosomal‐targeting receptor with established clinical relevance. TROP2‐targeting chimeras (TRTACs) are developed by genetically fusing a TROP2‐binding nanobody to nanobodies against specific target proteins.
Luping Chen, Xinying Fu, Wenqian Dong, Xiaobei Deng, Simin Chen, Fujun Wang, Jian Zhao, Shiqun Shao, Liqiang Fan, Jingyu Zhang, Lixin Zhang   +10 more
wiley   +1 more source

Engineered Allosteric Biosensor for In Situ DNA Glycosylase Detection in Neuroblastoma Risk Stratification and Drug Resistance Monitoring

Advanced Science, EarlyView.
An engineered allosteric biosensor (UUU‐DZ‐tFNA) was developed, in which UDG specifically recognizes and activates a DNAzyme to achieve signal cycle amplification in a sequentially activatable mode. UUU‐DZ‐tFNA achieves in situ UDG detection across multiple biological levels and facilitates risk stratification and drug resistance monitoring of NB ...
Yaqing Lu, Yingyu Zhang, Xianwei Zhang, Mengxin Zhang, Fei Zhang, Jushan Sun, Yahui Yang, Kangbo Liu, Peng Wang, Shuying Luo, Wancun Zhang   +10 more
wiley   +1 more source

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Colorectal neoplasm and acromegaly

Pituitary, 2006
The risk for colorectal carcinoma in acromegaly remains controversial. In our earlier study, we have demonstrated that the risk of colorectal carcinoma in Asian Indians with acromegaly is not increased and after this report, routine colonoscopy in our patients with acromegaly was abandoned.
Anil, Bhansali, Pinaki, Dutta, Mohammad Hayat, Bhat, S K, Sinha, R, Kochar, K, Vaiphi   +5 more
openaire   +2 more sources

Atypical Colorectal Neoplasms

Surgical Clinics of North America, 2017
Primary colorectal lymphoma, carcinoids (neuroendocrine tumors), and gastrointestinal stromal tumors comprise a small subset of all colorectal cancers. Their features are unique, and their treatment varies from that of colorectal adenocarcinoma. Appropriate identification is key in the management of these tumors.
Michael G, Porter, Scott M, Stoeger
openaire   +2 more sources

Flat and depressed colorectal neoplasms

Current Opinion in Gastroenterology, 2003
An increasing body of literature is available showing the existence of flat and depressed colorectal neoplasms in Western countries. The appreciation that colorectal neoplasms may present as flat or depressed lesions has important implications, as the risk of adenocarcinoma in depressed lesions has been found to be markedly higher than in flat or ...
Roy M, Soetikno, Lyn Sue, Kahng, Akiko, Ono, Takahiro, Fujii   +3 more
openaire   +2 more sources

Laparoscopic surgery for colorectal neoplasms

Seminars in Surgical Oncology, 1994
AbstractLaparoscopy is being used to assist in an increasing number and variety of bowel procedures. However, when being used for neoplastic disease concerns of margins and adequacy of mesenteric dissection must be addressed. We've performed 110 laparoscopic‐assisted bowel procedures, with 45 of these performed for neoplastic disease.
W L, Ambroze, G R, Orangio, D, Armstrong, M, Schertzer, G, Lucas   +4 more
openaire   +2 more sources