Results 41 to 50 of about 353,689 (293)

Clinical Correlates of Health Preference and Generic Health-related Quality of Life in Patients with Colorectal Neoplasms [PDF]

, 2013
Background: The aims of the study were to assess the health preference and health-related quality of life (HRQOL) in patients with colorectal neoplasms (CRN), and to determine the clinical correlates that significantly influence the HRQOL of patients ...
Poon, TCJ, Lam, CLK, Wong, CKH, Kwong, DLW   +3 more
core   +1 more source

The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo, Miriam A. Bornhorst, Angela J. Waanders, Sara Zarnegar‐Lumley, Ashwin Lakshman Koppayi, Lucy A. Godley   +5 more
wiley   +1 more source

Letters to the Editor Concerning the Article: Alexandre Oliveira Ferreira, Andrea Riphaus. Propofol to Increase Colorectal Cancer Screening in Portugal. Acta Med Port 2014;27:541-42.

Acta Médica Portuguesa, 2014
Keywords: Colorectal Neoplasms; Hypnotics and Sedatives; Propofol; Endoscopy, Gastrointestinal; Colonoscopy.
Francisco Almeida Lobo, António Rodrigues Melo   +1 more
doaj   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Survival in older adults with colorectal cancer: a literature review

Archivo Médico de Camagüey, 2021
Background: colorectal cancer is the most common malignant neoplasia that can occur in the digestive system. There has been a gradual increase in Latin America, Cuba presents health indicators similar to developed nations, and colorectal cancer is the ...
Belkis Alvarez-Escobar, Juan Carlos Mirabal-Requena, Ydalsys Naranjo-Hernández, Viviana Valdés-Alvarez   +3 more
doaj  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Patient and gross appearance characteristics of colorectal neoplasms. [PDF]

, 2022
Patient and gross appearance characteristics of colorectal neoplasms.
Seng-Kee Chuah (405052), Yu-Chi Li (5724938), Yeh-Pin Chou (414283), Yi-Chun Chiu (311694), Chih-Chien Yao (9988813), Ming-Luen Hu (13924596), Chen-Yu Ko (13924593), Lung-Sheng Lu (618979), Wei-Chen Tai (405051)   +8 more
core   +1 more source

Effects of supplemental vitamin D and calcium on markers of proliferation, differentiation, and apoptosis in the normal colorectal mucosa of colorectal adenoma patients.

PLoS ONE, 2018
To clarify the roles of vitamin D and calcium as potential chemopreventive agents against colorectal cancer in humans, and to develop "treatable", pre-neoplastic, phenotypic biomarkers of risk for colorectal neoplasms, we estimated the effects of ...
Yasheen Gao, Caroline Y Um, Veronika Fedirko, Robin E Rutherford, March E Seabrook, Elizabeth L Barry, John A Baron, Roberd M Bostick   +7 more
doaj   +1 more source