Results 51 to 60 of about 378,954 (344)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Colorectal Neoplasms in Young Vietnamese Individuals with First-degree Relatives Diagnosed with Colorectal Cancer

Siriraj Medical Journal
Objective: Colorectal cancer (CRC) is increasingly prevalent, particularly among individuals with first-degree relatives (FDRs) diagnosed with CRC. Delayed colonoscopy beyond the recommended age increases the risk of advanced neoplasia and late-stage ...
Doan Thi Nha Nguyen, Nhu Thi Hanh Vu, Mai Ngoc Luu, Quang Dinh Le, Truc Le Thanh Tran, Vy Ly Thao Tran, Huy Minh Le, Duc Trong Quach   +7 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Survival in older adults with colorectal cancer: a literature review

Archivo Médico de Camagüey, 2021
Background: colorectal cancer is the most common malignant neoplasia that can occur in the digestive system. There has been a gradual increase in Latin America, Cuba presents health indicators similar to developed nations, and colorectal cancer is the ...
Belkis Alvarez-Escobar, Juan Carlos Mirabal-Requena, Ydalsys Naranjo-Hernández, Viviana Valdés-Alvarez   +3 more
doaj  

Artificial intelligence for non‐polypoid colorectal neoplasms [PDF]

Digestive Endoscopy, 2020
The miss rate of flat advanced colorectal neoplasia is still unacceptably high, especially in the Western setting, notwithstanding the widespread implementation of quality improvement programs and training. It is well known that flat morphology is associated with miss rate of colorectal neoplasia, and that this subset of lesions often shows a more ...
Hassan C, Bhandari P, Antonelli G, Repici A   +3 more
openaire   +2 more sources

A Novel Opportunity in Minimally Invasive Colorectal Cancer Therapy: Defining a Role for Endoscopic Submucosal Dissection in the United States [PDF]

, 2013
Colorectal cancer is the third most common cancer among both men and women in the United States and the second leading cause of cancer death.
Cohen, Jonah
core   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Effects of antithrombotic drugs on the results of fecal immunochemical test in colorectal neoplasms screening

Scientific Reports, 2021
Fecal immunochemical test (FIT) is widely used as a colorectal cancer screening tool. Antithrombotic drugs may affect the screening performance of FIT for colorectal tumors.
Takashi Ibuka, Seiji Adachi, Yohei Horibe, Tomohiko Ohno, Masatoshi Mabuchi, Yusuke Suzuki, Osamu Yamauchi, Eri Takada, Midori Iwama, Koshiro Saito, Masamichi Arao, Koji Takai, Hiroshi Araki, Masahito Shimizu   +13 more
doaj   +1 more source

The ability of HALP score to distinguish between malignant and benign colorectal neoplasms and its prognostic importance in colorectal cancers

Medicine Science, 2023
Systemic inflammation and nutritional status play important roles in the development and progression of various cancers, including colorectal cancer. The prognosis for malignancies can be predicted using the inflammatory marker known as HALP (calculated ...
Ibrahimhalil Dusunceli, Zeynep Gok Sargin, Umut Celik, Fatih Sargin   +3 more
doaj   +1 more source