Results 131 to 140 of about 238,668 (252)

Promoter Hypermethylation‐Induced Silencing of FXYD1 Drives Breast Cancer Metastasis via DDX5‐Mediated Wnt/β‐Catenin Pathway Activation

Advanced Science, EarlyView.
This study identifies FXYD1 as an epigenetically silenced tumor suppressor in breast cancer. DNA methylation turns off the gene FXYD1 in breast cancer, and low levels predict worse outcomes. Restoring FXYD1 limits breast cancer cells proliferation and metastasis. In the nucleus, FXYD1 recruits the E3 ligase MAEA to K63‐ubiquitinate DDX5 for proteasomal
Ping Wen, Fanli Qu, Long Wang, Qing Shao, Sisi Li, Yang Qin, Dongping Jiang, Senmiao Zhang, Jiangdong Sui, Guanwen Wang, Ningning Zhang, Xiaohua Zeng   +11 more
wiley   +1 more source

Evaluating the Role of Retrieval Bags in Mitigating Contamination During Minimally Invasive Colorectal Surgery. [PDF]

J Clin Med
Valdes-Hernandez J, Balla A, Mittermair C, Obrist C, Gómez-Rosado JC, Pimpl K, Brunner E, Schirnhofer J, Weiss H, Morales-Conde S.   +9 more
europepmc   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Current Evidence in Robotic Colorectal Surgery. [PDF]

Cancers (Basel)
Willis F, Amati AL, Reichert M, Hecker A, Vilz TO, Kalff JC, Willis S, Kröplin MA.   +7 more
europepmc   +1 more source

Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond

Advanced Science, EarlyView.
Therapeutic gases, including NO, CO, H2S, H2, CO2, O2, and Xe, play vital roles in cellular signaling and repair. This review highlights the emerging carriers and delivery systems that enable controlled, localized gas release for diagnostic and therapeutic applications.
Syed Muntazir Andrabi, Navatha Shree Sharma, Imran Ibn Gani Rather, S. M. Shatil Shahriar, Jingwei Xie   +4 more
wiley   +1 more source

Anastomotic Leakage After Colorectal Surgery: Exploratory Analysis of Perioperative Risk Factors in a 672-Patient Cohort. [PDF]

Cureus
Buniatov T, Weidinger C, Krautz C, Brunner M, Francis RCE, Gruetzmann R, Maak M.   +6 more
europepmc   +1 more source

PRELID1 and VDAC3 Coordinate a Senescence‐Like State in Germinal Center B Cells to Promote IL‐7–Driven Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
Colorectal cancer is characterized by an immunosuppressive microenvironment that limits immunotherapy efficacy. We identify a senescence‐like state in germinal center B cells driven by the PRELID1–VDAC3 axis, which promotes IL‐7 secretion, alleviates CD8+ T‐cell exhaustion, and enhances antitumor immunity. Targeting this pathway improves responsiveness
Yuhan Liao, Huimeng Xu, Xinghua Zhuo, Shupeng Hu, Lanhui Huang, Zhe Hao, Jianxiong Chen, Yulu Wang, Jun Zhou   +8 more
wiley   +1 more source

Multicenter international experience with the Hugo™ RAS platform in colorectal surgery: reproducibility and real-world outcomes from the COLOROBOT IBERICA study. [PDF]

J Robot Surg
Sánchez-Guillén L, Brandao P, Romero-Marcos JM, Tabet-Almeida J, Gómez-Díaz CJ, Báguena-Requena G, Santos M, Delgado-Rivilla S, López-Bañeres M, Collera-Ormazabal P, Blanco-González FJ, Barber X, Arroyo A.   +12 more
europepmc   +1 more source

Tumor‐Derived Exosomal TAGLN2 Promotes Metastasis by Inducing Vascular Permeability and Angiogenesis via the NRP1/SEMA4D/YAP Axis

Advanced Science, EarlyView.
Gastric cancer‐derived exosomal TAGLN2 is identified as a key mediator of vascular reprogramming, with significantly elevated levels detected in patient serum. Independent of canonical SEMA4D signaling, it nucleates a cytoplasmic TAGLN2/NRP1/SEMA4D ternary complex that dually activates YAP, promoting angiogenesis, vascular dysfunction, and metastasis ...
Shuqi Yu, Jiajia Zhuo, Xiaoquan Hong, Shihao Rao, Yafang Ye, Dandan Kang, Huifang Peng, Huiqin Zhuo   +7 more
wiley   +1 more source

Use of Robotics in Colorectal Surgery: An Initial Single-Centre Experience. [PDF]

Cureus
Agarwal A, Lala A, Rehman SFU, Dixon S, Whiteley G, Pouwels S, Ahmed A, Ahmad S.   +7 more
europepmc   +1 more source